Triamcinolone/ Econazole

Registered South African indications: 

Corticosteroid-responsive dermatoses with secondary infections caused by:

• Dermatophytes
• Yeasts (including Candida spp., Rhodotorula, Pityrosporon ovale)
• Moulds

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Specific skin conditions such as tuberculosis, varicella, herpes simplex or other viral infections of the skin
• Fresh vaccination sites

Cautions

Caution in the following patient groups

• Pregnancy
• Breastfeeding

Ophthalmic use

• Avoid ophthalmic use

Prolonged applications

• Avoid prolonged applications to thin skin and to the face. Potent topical corticosteroid preparations (triamcinolone) should not be applied to any skin crease areas

Forms avail. in SA and covered in this monograph: cre

Corticosteroid-responsive dermatoses with secondary infections caused by: Dermatophytes; Yeasts (including Candida spp., Rhodotorula, Pityrosporon ovale); Moulds

Triamcinolone/ Econazole
50/150 (mg/15g)

• Topical (cre): Apply small quantity to affected area(s), 12hrly in morning and night; Max treatment duration: 2 weeks

Do not use occlusive dressing

Not established for use in children below 3 months

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• Caution; not recommended

Breastfeeding

• Caution; not recommended

Renal Impairment

• No dose adjustment recommended (Triamcinolone, Econazole)

Hepatic Impairment

• No dose adjustment recommended (Triamcinolone, Econazole)

Elderly

• No dose adjustment recommended (Triamcinolone, Econazole)

Porphyria Information

• Not yet classified (NC)

Drugs in Sport

• Permitted - No warnings

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Triamcinolone
Central Nervous System Disorders

• Insomnia
• Headache
• Dizziness
• Fatigue

Respiratory Disorders

• Flu syndrome
• Pharyngitis
• Rhinitis
• Bronchitis 
• Epistaxis
• Cough
• Nasal septum perforation
• Nasal irritation
• Dry mucous membranes
• Nasal congestion
• Sneezing
• Dyspnoea

Gastrointestinal Disorders

• Dyspepsia
• Tooth disorder
• Nausea

Skin and Subcutaneous Tissue Disorders

• Rash
• Urticaria
• Pruritis

Immune, Blood and Lymphatic System Disorders

• Hypersensitivity

Sensory Disorders

• Alterations to taste and smell
• Cataract
• Glaucoma
• Increased ocular pressure

Econazole
Skin and Subcutaneous Tissue Disorders

• Pruritus
• Burning sensation of skin
• Rash
• Erythema
• Angioedema
• Urticaria
• Contact dermatitis
• Skin exfoliation
• Blister
• Application site pain
• Application site irritation
• Application site swelling

Immune, Blood and Lymphatic System Disorders

• Hypersensitivity

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Triamcinolone

• Oral corticosteroids 

Econazole

• CYP3A4 substrates
• CYP2C9 substrates
• Oral anticoagulants
• Latex 
• Spermicidal contraceptives

None routine. Specific cases may require

• Growth (children)
• Coagulation studies

Triamcinolone
Triamcinolone is a synthetic glucocorticosteroid that is approximately 8 times more potent than prednisone. The precise mechanism of action is not known but through control of protein synthesis, depression of leukocyte and fibroblast migration and effects on capilliary permeability, triamcinolone has good anti-inflammatory actions.

Econazole
Econazole inhibits the synthesis of the fungal cell membrane, which results in increased cellular permeability and leakage of cellular contents.

COMBINATION PREPARATIONS

Econazole/ Triamcinolone

Cream (per 15g) 150/15mg

• Pevisone (Janssen) originator