Circular 12 December 2025: Notice - Flucytosine 500mg Tablet Stock Supply and Implications for the Treatment of Cryptococcal Meningitis
The 2024 Adult Hospital Level and 2023 Paediatric Hospital Level editions of the Standard Treatment Guidelines (STGs) and Essential Medicines List (EML) currently recommend oral flucytosine as a critical part of the induction phase treatment regimen of cryptococcal meningitis (CCM) used in combination with intravenous amphotericin B and oral fluconazole. Recently, the supply of oral flucytosine h
The 2024 Adult Hospital Level and 2023 Paediatric Hospital Level editions of the Standard Treatment Guidelines (STGs) and Essential Medicines List (EML) currently recommend oral flucytosine as a critical part of the induction phase treatment regimen of cryptococcal meningitis (CCM) used in combination with intravenous amphotericin B and oral fluconazole. Recently, the supply of oral flucytosine has been inconsistent.