GuidelinesOther guideline
Community Acquired Sepsis of Unknown Origin
Infection Community acquired sepsis of unknown origin Brief outline/clinical setting Non-neutropenic adult with a clinical syndrome of sepsis where a source has not/cannot be identified Patient has signs of organ dysfunction and requires admission Aetiologies/organisms S.aureus, E.coli, K.pneumoniae, E.cloacae, Proteus spp, Enterococcus spp, S.pneumoniae, N.meningitidis , anaerobic organisms unco
| Infection | Community acquired sepsis of unknown origin |
|---|---|
| Brief outline/clinical setting | Non-neutropenic adult with a clinical syndrome of sepsis where a source has not/cannot be identified Patient has signs of organ dysfunction and requires admission |
| Aetiologies/organisms | S.aureus, E.coli, K.pneumoniae, E.cloacae, Proteus spp, Enterococcus spp, S.pneumoniae, N.meningitidis, anaerobic organisms uncommon |
| Optimal antimicrobial selection | Cefuroxime 1.5g IVI 8hrly |
| Duration | Maximum 72 hrs- culture results and source should be available in order to tailor therapy/alternative diagnosis made |
| Alternative if allergic/not available | Amoxicillin- clavulanate 1.2g IVI 8hrly |
| Rationale | Local epidemiology and antibiogram |
| Level of evidence | Moderate |