GuidelinesEML (Adult Hospital STG)
Cotrimoxazole Desensitisation
Standard Treatment Guidelines and Essential Medicines List for South Africa, Hospital Level, Adults 2019 Edition
- Attempt desensitisation in patients with a history of cotrimoxazole intolerance, unless this was life-threatening, e.g.: Stevens-Johnson syndrome. (See Erythema Multiforme, Stevens Johnson Syndrome, Toxic Epidermal Necrolysis).
- Unless the rash is severe or associated with systemic symptoms, continue treatment with careful observation for deterioration.
- Desensitisation should be attempted using cotrimoxazole suspension 240 mg/5ml. Dilute the suspension appropriately and consult with your pharmacist if necessary.
Note: Do not administer antihistamines or steroids with this regimen.
| Time (hours) | Cotrimoxazole dose (mL of 240mg/5mL suspension |
| 0 | 0.0005 |
| 1 | 0.005 |
| 2 | 0.05 |
| 3 | 0.5 |
| 4 | 5 |
| 5 | Two single strength tablets (each tablet = 80/400 mg) followed by full dose |
Standard Treatment Guidelines and Essential Medicines List for South Africa, Hospital Level, Adults 2019 Edition