GuidelinesOther guideline
Cryptococcal Meningitis
Infection Cryptococcal meningitis Brief outline/clinical setting Common opportunistic pathogen causing meningitis in advanced HIV disease Aetiologies/organisms Cryptococcus neoformans, Cryptococcus gattii Optimal antimicrobial selection Induction: - Amphotericin B deoxycholate 1mg/kg IVI daily + Flucytosine 100mg/kg/day in 4 doses x 1 week - Then fluconazole 1200mg daily x 1 week Consolidation: -
| Infection | Cryptococcal meningitis |
| Brief outline/clinical setting | Common opportunistic pathogen causing meningitis in advanced HIV disease |
| Aetiologies/organisms | Cryptococcus neoformans, Cryptococcus gattii |
| Optimal antimicrobial selection | Induction: - Amphotericin B deoxycholate 1mg/kg IVI daily + Flucytosine 100mg/kg/day in 4 doses x 1 week - Then fluconazole 1200mg daily x 1 week Consolidation: - Fluconazole 800mg daily x 8 weeks Maintenance: - Fluconazole 200mg x minimum 1 year |
| Duration | |
| Alternative if allergic/not available | Discuss with Infectious Diseases/ Microbiology |
| Rationale | |
| Level of evidence | High |
| Link to Guideline | Click here |