GuidelinesEML (Adult Hospital STG)
Discontinuation Symptoms of Serotonin Reuptake Inhibitors
ICD-10 code: F19.3 + (Y49.2) Discontinuation symptoms are experienced due to receptor adaptation or receptor rebound after stopping of antidepressants. It can be avoided or reduced by slowly tapering the drug over at least 4 weeks. Symptoms include flu-like symptoms, ‘shock-like” sensations, dizziness exacerbated by movement, insomnia, vivid dreaming and irritability, problems with concentr
ICD-10 code: F19.3 + (Y49.2)
- Discontinuation symptoms are experienced due to receptor adaptation or receptor rebound after stopping of antidepressants. It can be avoided or reduced by slowly tapering the drug over at least 4 weeks.
- Symptoms include flu-like symptoms, ‘shock-like” sensations, dizziness exacerbated by movement, insomnia, vivid dreaming and irritability, problems with concentration, and memory or movement disorders.
- It is managed by reintroduction of the SSRI and slower tapering of the dose.
Note:
Fluoxetine seldom causes discontinuation symptoms because of its long half-life.
Standard Treatment Guidelines and Essential Medicines List for South Africa, Hospital Level, Adults_Chapter 15: Mental Health Conditions and Substance Misuse_NEMLC Recommendations for Medicine Amendments 2020-2023