Drug-Resistant Tuberculosis (MDR TB)

Drug-resistant TB (DR-TB) guidelines are updated regularly.   Consult the most recent National DR-TB Programme Guidelines.

DESCRIPTION

• Isoniazid monoresistant TB is TB disease caused by M. tuberculosis that is resistant to isoniazid, but susceptible to rifampicin
• Rifampicin resistant tuberculosis (RR-TB) is TB disease caused by M. tuberculosis that is resistant to rifampicin, with or without resistance to other anti-TB drugs
• Pre-XDR TB is TB disease caused by a strain of M. tuberculosis that is resistant to rifampicin and at least one fluoroquinolone (either levofloxacin or moxifloxacin)
• Extensively drug-resistant TB (XDR-TB) is TB disease caused by a strain of M. tuberculosis that is resistant to rifampicin AND at least one fluoroquinolone (levofloxacin or moxifloxacin) AND either bedaquiline or linezolid

LoE:IVb⁴⁷

See:  Isoniazid mono-resistant tuberculosis in adults

See:  Rifampicin-resistant tuberculosis (RR TB), in adults

See:  Rifampicin-resistant (RR), pre-XDR and XDR tuberculosis, in children

Click here to access the pdf.

---

Standard Treatment Guidelines and Essential Medicines List for South Africa, Primary Healthcare, 2020-4-Version 1.0_16 September 2024

Chapter 17: Respiratory Conditions_17.4 Pulmonary Tuberculosis (TB)_17.4.4 Drug-Resistant Tuberculosis (MDR TB)