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Eczema, Atopic

Eczema and Dermatitis

Please click on the link below to access the most up-to-date version of this guideline. The content on this page is currently being updated to align with the latest publication. Always check the version number at the bottom of the screen to confirm which version you are using.

Click here to access the Primary-Healthcare-Chapter-5-Skin-Conditions-with-Supporting-NEMLC-Report-2020-4-Review-Version-2.0-November-2025


Description

General Measures

Medicine Treatment

Referral


ICD 10 code: L20.0/L20.8-9

DESCRIPTION

  • An inflammatory disorder with an itchy red rash or dry rough skin
  • In babies it appears at approximately 3 months
  • Family history of asthma, hay fever or atopic dermatitis is common
  • Clinical features:
    • Occurs on the inner (flexural) surfaces of elbows and knees, the face and neck
    • Can become chronic with thickened scaly skin (lichenification)
    • Secondary bacterial infection may occur with impetigo or pustules
    • Can be extensive in infants
    • Very itchy at night
  • Eczema is usually a chronic condition and requires long term care. 
  • Sufferers of atopic eczema are particularly susceptible to herpes simplex and may present with large areas of involvement with numerous vesicles and crusting surrounded by erythema (eczema herpeticum). See: Herpes simplex

GENERAL MEASURES

  • Avoid direct skin contact with woollen or rough clothes
  • Avoid overheating by blankets at night
  • Trim fingernails to prevent scratching
  • Counsel on good personal hygiene with regular washing to remove crusts and accretions and to avoid secondary infection
  • Diet modification may have no role in atopic eczema treatment
  • Avoid soap on affected areas

MEDICINE TREATMENT

(For management of severe eczema, start at step 3)

STEP 1

  • Avoid soap, use soap substitutes such as aqueous cream (UEA)
    • Rub on skin, before rinsing off completely
    • Do not use aqueous cream as an emollient
  • Emollient, e.g.:
    • Emulsifying ointment (UE)

If no response within seven days; or more severe eczema:

STEP 2

  • Hydrocortisone 1%, topical, applied twice daily for 7 days
    • Apply sparingly to the face
    • Do not apply around the eyes

If there is a response:

Reduce the use of the hydrocortisone cream to once daily for a further few days, then stop and maintain treatment with:

  • Aqueous cream (UEA) as a wash-off soap

AND

  • Emollient, e.g.:
    • Emulsifying ointment (UE)

If no response within seven days or more severe eczema:

STEP 3

Corticosteroid, potent, topical, e.g.: (Doctor prescribed)

  • Betamethasone 0.1%, topical, apply ointment once daily for 7 days 
    • Do not apply to face, neck and flexures

LoE: IIb20

If there is a response:

Reduce use of corticosteroid ointment for a further few days, then stop and maintain treatment with:

  • Aqueous cream (UEA) as a soap

AND

  • Emollient, e.g.:
    • Emulsifying ointment (UE)

If the patient is itching:

Children

  • Chlorphenamine, oral, 0.1 mg/kg/dose at night for a maximum of 2 weeks. See: dosing table

LoE:IVb21

Adults

  • Chlorphenamine, oral, 4 mg, at night for a maximum of 2 weeks

Note:
Chlorphenamine is sedating.


If itch is not controlled or is more severe during the day, switch to: 

Children: 2–6 years of age

Children > 6 years of age and adults

  • Cetirizine, oral, 10 mg once daily

LoE:IVb

REFERRAL

  • No improvement in 2 weeks
  • Infants and children requiring more than 1% hydrocortisone cream
  • Extensive involvement
  • Eczema herpeticum

Click here to access the pdf.


Standard Treatment Guidelines and Essential Medicines List for South Africa, Primary Healthcare, 2020-2024_Version 1.0_07 November 2024

Chapter 5: Skin Conditions_5.8.1 Eczema, Atopic

Drugs mentioned

ICD-10 codes

NeoHealth® ID 20760 · updated 4/28/2026