Hepatitis, Chronic, Autoimmune
Description Diagnostic criteria Medicine treatment Referral ICD-10 code: K75.4 DESCRIPTION Autoimmune induced hepatitis. DIAGNOSTIC CRITERIA Clinical Jaundice. Hepatosplenomegaly. Cutaneous features of chronic liver disease. Extrahepatic manifestations of the autoimmune process. Investigations Elevated bilirubin and transaminases. Hypoalbuminaemia and prolonged prothrombin time/INR. Auto-im
Description
Diagnostic criteria
Medicine treatment
Referral
ICD-10 code: K75.4
DESCRIPTION
Autoimmune induced hepatitis.
DIAGNOSTIC CRITERIA
Clinical
- Jaundice.
- Hepatosplenomegaly.
- Cutaneous features of chronic liver disease.
- Extrahepatic manifestations of the autoimmune process.
Investigations
- Elevated bilirubin and transaminases.
- Hypoalbuminaemia and prolonged prothrombin time/INR.
- Auto-immune marker screen.
- Total serum globulin or gammaglobulin or IgG greater than 1.5 times upper normal limit.
- Diagnosis confirmed on liver biopsy.
MEDICINE TREATMENT
Induction therapy:
- Corticosteroids. Specialist initiated.
Maintenance therapy:
- Azathioprine. Specialist initiated.
REFERRAL
- All for confirmation of diagnosis and initiation of treatment.
Standard Treatment Guidelines and Essential Medicines List for South Africa Paediatric Hospital _2023, 5th edition_Updated July 2024
Chapter 2: Alimentary Tract, 2.3 Hepatic Disease, 2.3.8 Hepatitis, Chronic, Autoimmune