Herpes Simplex Ulcers, Chronic
Please click on the link below to access the most up-to-date version of this guideline. The content on this page is currently being updated to align with the latest publication. Always check the version number at the bottom of the screen to confirm which version you are using. Click here to access the Primary Health Care - PHC Chapter 11: Human Immunodeficiency Virus and Acquired Immune Deficienc
Please click on the link below to access the most up-to-date version of this guideline. The content on this page is currently being updated to align with the latest publication. Always check the version number at the bottom of the screen to confirm which version you are using.
Click here to access the Primary Health Care - PHC Chapter 11: Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV and AIDS) - 26 February 2026
B20.3 + (B00.1-2)
DESCRIPTION
Painful ulcers due to herpes simplex virus, involving the skin around the anogenital area or in and around the mouth and nostrils in patients with advanced HIV infection. Ulcers persist for weeks and may be several centimetres in diameter.
GENERAL MEASURES
Keep affected areas clean with soap and water or diluted antiseptic solution.
MEDICINE TREATMENT
- Antiviral (active against herpes simplex) e.g.:
- Aciclovir, oral, 400 mg 8 hourly for 7 days.
- Commence ART.
LoE:IIIb42
Pain:
- Paracetamol, oral, 500mg-1 g 4–6 hourly when required (maximum of 4g in 24 hours).
- Maximum dose: 15 mg/kg/dose.
REFERRAL
- No response to therapy.
- Frequent recurrences.
Standard Treatment Guidelines and Essential Medicines List for South Africa, Primary Healthcare, 2020-2024_Version 2.1_09 December 2024
Chapter 11: Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (HIV AND AIDS)_11.3 Opportunistic Infections, Treatment in Adults_11.3.10 Herpes Simplex Ulcers, Chronic