GuidelinesOther guideline
Infective Endocarditis (Native Valve)
Infection Infective Endocarditis (Native Valve) Brief outline/clinical setting IE is associated with significant morbidity and mortality. The epidemiology of IE is changing however there is a lack of local data. Aetiologies/organisms S.aureus, Viridans Streptococci , Enterococcus spp. HACEK group organisms, Optimal antimicrobial selection Ampicillin 2 g IVI 4hrly (total 12 g/day) doses + Cloxacil
| Infection | Infective Endocarditis (Native Valve) |
|---|---|
| Brief outline/clinical setting | IE is associated with significant morbidity and mortality. The epidemiology of IE is changing however there is a lack of local data. |
| Aetiologies/organisms | S.aureus, Viridans Streptococci, Enterococcus spp. HACEK group organisms, |
| Optimal antimicrobial selection | Ampicillin 2 g IVI 4hrly (total 12 g/day) doses + Cloxacillin 2 g IVI 4hrly (total 12g/day) + Gentamicin 3 mg/kg/day i.v. or i.m. as a single daily dose. Tailor therapy based on culture results |
| Duration | Dependent on organism implicated: Watch for interstitial nephritis – daily U&E&Cr initially |
| Alternative if allergic/not available | Discuss with Microbiology |
| Rationale | |
| Level of evidence | High |
| Link to Guideline | Click here |