GuidelinesOther guideline
Infusion: Amiodarone
Amiodarone Infusion
| Trade names: | Presentation and strength: |
| Cordarone X. Amiotach. | 150mg/3ml ampoules. |
| Cautions: see SAMF. | |
| Amiodarone is incompatible with saline – mix with D5W only. Correct hypokalaemia – amiodarone may be ineffective or arrythmogenic. Use a large vein or central line – thrombophlebitis of peripheral veins is common. IV bolus is associated with hypotension – infusion is preferred method. Unsafe in porphyria (avoid sunlight exposure). Contra-indicated in 2nd and 3rd degree AV block. Caution with beta blockers and calcium antagonists. | |
| Loading dose: | |
| Adult: Acute resuscitation: slow IV bolus of 150mg to 300mg over 1 to 2 minutes. Otherwise slow IV infusion: 5mg/kg over 20 mins. Follow with a constant infusion 900 mg over 24 hrs | Paediatric: Not for paediatric use. |
| Commonly for 70kg adult: 350 to 400mg diluted in 100 to 200ml D5W over 20 to 30 minutes. | Neonatal: Not for neonatal use. |
| Constant infusion: | |
| Adult dosage range: 0.4 to 0.7mg/kg/hr. | Paediatric dosage range: N/A |
| Neonatal dosage range: N/A | |
| Regime for 70kg adult: | Regime for paediatrics: |
| Mixture: Dilute 600mg (4 amps or 12ml) into 50ml D5W = 12mg/ml. | Mixture: N/A |
| Rate: 28 to 50mg/hr = 2.3 to 4.2ml/hr. | Rate: N/A |
| Alternative adult regime: | Alternative paediatric regime: |
| Mixture: Mainenance dose for 70kg patient after loading-dose infusion completed: Mix 600mg (4 amps or 12ml) in 500ml D5W. | Mixture: N/A |
| Rate: Run at 23 to 42ml/hr. | Rate: N/A |