GuidelinesOther guideline
Infusion: Dobutamine
DOBUTAMINE INFUSION
| Trade names: | Presentation and strength: |
| Dobutrex | 250mg in 20ml ampoules (25mg/ml) |
| Cautions: see SAMF. | |
| Avoid in diluents containing sodium bicarbonate. Can be mixed with saline or D5W. Administer via central line or large peripheral line – be extremely cautious of vasoconstriction, ischaemic pain and local necrosis. | |
| Loading dose: | |
| Adult: N/A | Paediatric: N/A |
| Commonly for 70kg adult: N/A | Neonatal: N/A |
| Constant infusion: | |
| Adult dosage range: 5 to 20mcg/kg/min. (can go up to 40mcg/kg/min) | Paediatric dosage range: 5 to 20mcg/kg/min: |
| Neonatal dosage range: As above. | |
| Regime for 70kg adult: | Regime for paediatrics: |
| Mixture: 250mg in 50ml total volume = 5mg/ml. 500mg in 100ml total volume = 5mg/ml. | Mixture: <30kg: 15mg/kg in 50ml. |
| Rate: 5mcg/70kg/min = 4.2ml/hr. 10mcg/70kg/min = 8.4ml/hr. 20mcg/70kg/min = 16.8ml/hr. 40mcg/70kg/min = 33.6ml/hr. (rarely needed) | Rate: 1 to 4ml/hr. |
| Alternative adult regime: | Alternative paediatric regime: |
| Mixture: (infusion pump) 500mg in 200ml = 2.5mg/ml. | Mixture: If greater volumes required for larger children, can stay with above, or: >30kg: 6mg/kg in 100ml. |
| Additional notes: | |
| Add heparin 1u/ml to the solution. Caution with dilutions – heparin is available as 1000u/ml and 5000u/ml. If 1000u/ml then: 0.1ml = 100u (use insulin syringe). | |