GuidelinesOther guideline
Infusion: Glyceryl Trinitrate
GLYCERYL TRINITRATE INFUSION
| Trade names: | Presentation and strength: |
| Tridil, Nitrocine. | 1mg/ml as 10ml ampoules. 50ml vials. |
| Cautions: See SAMF. | |
| Up to 80% of GTN is absorbed by PVC giving sets and plastic IV fluid bags. Use minimum volume administration tubing. See additional notes below. | |
| Loading dose: | |
| Adult: Boluses of 0.1mg may be given. | Paediatric: N/A |
| Commonly for 70kg adult: 0.1ml bolus (use insulin syringe) for acute hypertensive emergencies. Beware precipitous BP drop. | Neonatal: N/A |
| Constant infusion: | |
| Adult dosage range: Start at 25 to 50mcg/min. Maximum rate 200mcg/min. | Paediatric dosage range: 0.5 to 5mcg/kg/min. |
| Neonatal dosage range: N/A. | |
| Regime for 70kg adult: | Regime for paediatrics: |
| Mixture: Use solution of 50mg/50ml. | Mixture: <30kg: 3mg/kg in 50ml D5W. |
| Rate: Start at 1.5 to 3ml/hr. Maximum rate 12ml/hr. Increase by 1ml/hr every 5 mins according to clinical response. | Rate: 0.5 to 5ml/hr. |
| Alternative adult regime: | Alternative paediatric regime: |
| Mixture: | Mixture: If greater volumes required for larger children, can stay with above, or: >30kg: 3mg/kg in 100ml D5W. |
| Rate: | Rate: 1 to 10ml/hr. |
| Additional notes: | |
| Due to GTN absorption by PVC tubing, use clinical response (blood pressure) and not calculated dose to establish a dose that is appropriate for the patient. Slow or stop infusion if patient becomes hypotensive. Dose escalation may be required due to tolerance developing | |