GuidelinesOther guideline
Infusion: Labetalol
Labetalol
| Trade names: | Presentation and strength: |
| Trandate | 5mg/ml in 20ml ampoules (100mg) |
| Cautions: see SAMF. Cardiac failure & Acute myocardial infarct be cautious of eliciting cardiogenic shock Caution when used with Calcium channel blockers Do not mix with sodium bicarbonate Caution with extravasation (good IV access) – tissue ischaemia & necrosis Reduce BP NO MORE than 25% of MAP | |
| Loading dose: | |
| Adult: Slow IV 5 – 20 mg (1-4ml) over 2 minutes Repeat bolus every 10 min till desired effect. Suggest using 5mg/1ml doses | Paediatric: See Infusion below |
| Commonly for 70kg adult: | Neonatal: As for paediatric. |
| Constant infusion: | |
| Adult dosage range: 200mg (40ml) Labetalol to 160ml N/Saline (or 5% Dex) total 200ml (1mg/ml) Rate 1-2ml/min (60-120ml/hr) = 1-2 mg/min | Paediatric dosage range: Neat Labetalol 5mg/ml at 1ml/hr = (5/weight) mg/kg/hr infusion Range of 0.5 – 3 mg/kg/hr |
| Neonatal dosage range: As for paediatric. | |
| Regime for 70kg adult: | Regime for paediatrics: |
| Mixture: 200mg Labetalol in 160ml N/Saline | Mixture: Labetalol neat suggest using syringe driver with 10-20 ml Labetalol |
| Rate: Run at 1ml/min (60-120ml/hr) | Rate: Run at 0.5 – 3 mg/kg/hr |
| Alternative adult regime: | Alternative paediatric regime: |
| Mixture: | Mixture: |
| Rate: | Rate: |
| Additional notes: | |