Neobook — clinical reference

Trade names:	Presentation and strength:
Mannitol	12.5g/50ml (25% m/v) = 250mg/ml.
Cautions: see SAMF. Must insert urinary catheter before administering mannitol.
Loading dose:
Adult: N/A.	Paediatric: N/A.
Commonly for 70kg adult: N/A	Neonatal: N/A.
Constant infusion:
Adult dosage range: 0.25 to 1g/kg given 6 to 8 hourly (GSH). 0.25 to 2g/kg given 6 to 8 hourly (SAMF).	Paediatric dosage range: As for adult.
	Neonatal dosage range: As for paediatric.
Regime for 70kg adult:	Regime for paediatrics:
Mixture: 12.5g/50ml (25% m/v) = 250mg/ml.	Mixture: 12.5g/50ml (25% m/v) = 250mg/ml.
Rate: 70 to 280ml rapidly (30 minutes).	Rate: 1ml/kg to 4ml/kg.
Alternative adult regime:	Alternative paediatric regime:
Mixture: 12.5g/50ml (25% m/v) = 250mg/ml.	Mixture: 12.5g/50ml (25% m/v) = 250mg/ml.
Rate: 70 to 560ml (SAMF).	Rate: 1ml/kg to 8ml/kg (SAMF).
Additional notes: Osmotic diuresis is indicated for controlling raised intracranial pressure in patients with brain oedema. Indications for mannitol infusion are: Deteriorating LOC. New onset focal signs. Suspected significantly raised ICP on clinical grounds (assuming an intracranial pressure monitor has not been placed). Give rapidly (GSH). [SAMF says give over 30 to 60 minutes.] Dose can be repeated (6-8 hourly) if the patient’s condition improves, remains improved, or if condition deteriorates after an initial improvement.

Infusion: Mannitol