GuidelinesOther guideline
Infusion: Midazolam
Midazolam Infusion
| Trade names: | Presentation and strength: |
Dormicum. | 5mg/5ml and 15mg/3ml ampoules. |
| Cautions: See SAMF. | |
| Loading dose: | |
| Adult: 0.05 to 0.2mg/kg IV. | Paediatric: 0.2 to 0.5mg/kg IV or IM. Administer 0.2mg/kg and repeat after 10 minutes if necessary. |
| Commonly for 70kg adult: 3.5 to 14mg Usually 5 to 10mg. May require higher dose. | Neonatal: As above. |
| Constant infusion: | |
| Adult dosage range: 1 to 4mcg/kg/min = 60 to 240mcg/kg/hr. | Paediatric dosage range: 1 to 4mcg/kg/min. |
| Neonatal dosage range: As above. | |
| Regime for 70kg adult: | Regime for paediatrics: |
| Mixture: Add 50mg in 50ml total volume = 1mg/ml. (Or 45mg in 45ml – 3 x 15mg ampoules). | Mixture: Add 3mg/kg into 50ml total volume. |
| Rate: For 70kg adult: 4.2mg/hr to 16.8mg/hr. 5 to 15ml/hr. | Rate: 1 to 4ml/hr. |
| Alternative adult regime: | Alternative paediatric regime: |
| Mixture: | Mixture: 10mg in 50ml = 0.2mg/ml. |
| Rate: | Rate: 1ml/kg/hr. [240mcg/kg/hr approximates 200mcg/kg/hr]. |
| Additional notes: Double the strength and halve the rate if volume restriction is required. | |