Introduction
The Primary Healthcare (PHC) and Adult Hospital Level (AHL) Standard Treatment Guidelines (STGs) and Essential Medicines List (EML) enable the equitable access to safe, effective and affordable essential medicines across South Africa. Historically, the PHC and AHL Expert Review Committees (ERCs) responsible for developing the PHC and AHL STGs were appointed as separate Committees. However, in 202
The Primary Healthcare (PHC) and Adult Hospital Level (AHL) Standard Treatment Guidelines (STGs) and Essential Medicines List (EML) enable the equitable access to safe, effective and affordable essential medicines across South Africa.
Historically, the PHC and AHL Expert Review Committees (ERCs) responsible for developing the PHC and AHL STGs were appointed as separate Committees. However, in 2020 the Committees were merged to streamline efforts and optimise resources, ensuring a seamless continuum of care between the PHC and AHL of care. The review cycle for these STGs commenced at the onset of the COVID-19 pandemic, necessitating a shift in priorities to address emerging needs and challenges faced by the healthcare system during the pandemic.
The ERC reviews the STGs and EML according to a topic prioritisation framework that includes consideration of clinical need, efficacy, safety, cost-effectiveness, feasibility and equity, presenting recommendations to the National Essential Medicines List Committee (NEMLC) for appraisal and ratification. The multidisciplinary team, which includes clinical experts, clinical pharmacologists and evidence-review and guideline-development methodologists has strengthened the STG development process. The National Department of Health’s Essential Drugs Programme team supports this process and has ensured collaboration and alignment with other advisory groups in updating these guidelines.
The NEMLC has incorporated the latest advances in clinical care into various disorder and chapter updates, expanding medicine treatment options including (but not limited to) Blood and Blood-Forming Organs, HIV, Mental Health, Obstetrics and Gynaecology, as well as Palliative Care. Notably, the AHL STGs and EML features a new chapter on Adult Critical Care, developed through extensive consultation across both public and private sectors. This chapter aims to enhance our response capabilities and ensure comprehensive care for critically ill patients.
The 2024 editions of the PHC and AHL STGs and EML reflects the National Department of Health’s commitment to continually evolving and enhancing the quality and accessibility of healthcare across our country.
DR SSS BUTHELEZI
DIRECTOR-GENERAL: HEALTH
DATE: 11 June 2025
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Standard Treatment Guidelines and Essential Medicines List for South Africa, Hospital Level, Adults 2024 Edition