Isoniazid Mono-Resistant Tuberculosis in Adults

Medicine Treatment

Referral

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A15.0-3/A15.7-8/A16.0-2/A16.4/A16.7-9 + (U50.00-01+U50.10-11) + (B20.0)

MEDICINE TREATMENT

Confirmed isoniazid mono-resistant TB:  

• RHZE at standard doses (See: Pulmonary tuberculosis (TB) in adults)

AND

• Levofloxacin, oral, daily
  • 30–45 kg: 750 mg
  • ≥ 46 kg: 1 000 mg

Confirmed isoniazid monoresistant TB AND contraindication to isoniazid:

• Rifampicin, oral, 10 mg/kg daily

AND

• Ethambutol, oral, 15 mg/kg daily

AND

• Pyrazinamide, oral, 25 mg/kg daily

AND

• Levofloxacin, oral, daily
  • 30–45 kg: 750 mg
  • > 46 kg: 1 000 mg

Treatment should be given for at least 6 months

LoE:IIb⁴⁸

REFERRAL

All drug resistant TB patients to medical officer at primary care level for initiation of therapy.

Click here to access the pdf.

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Standard Treatment Guidelines and Essential Medicines List for South Africa, Primary Healthcare, 2020-4-Version 1.0_16 September 2024

Chapter 17: Respiratory Conditions_17.4 Pulmonary Tuberculosis (TB)_17.4.4 Drug-Resistant Tuberculosis (MDR TB)_17.4.4.1 Isoniazid Mono-Resistant Tuberculosis in Adults