Malaria, Non-severe/Uncomplicated

Medicine Treatment

Referral

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ICD-10 codes: B50.9/B51.9/B52.9/B53.0/B54

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Note: notifiable medical condition.

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MEDICINE TREATMENT

• Artemether/ lumefantrine, oral, 20/120mg, with fat-containing food/ full cream milk to ensure adequate absorption.

  • Give the first dose immediately.
  • Follow with second dose 8 hours later.
  • Then 12 hourly for another 2 days (total number of doses in 3 days = 6).

^{Click on table to enlarge}

For fever in children <5 years of age:

Children

• Paracetamol, oral, 10–15 mg/kg/dose 6 hourly when required. See: dosing table.

REFERRAL

Urgent

• All patients with any sign of severe (complicated) malaria, See: Malaria, Severe/complicated
• All patients presenting to PHC clinics in areas that do not stock antimalarials.
• Vomiting leading to inability to retain medication.
• Patients not responding to oral treatment within 48 hours.
• After 1^st dose of artemether/ lumefantrine 20/120 mg:
  • All children <2 years of age.
  • Pregnant women.
  • Patients with co-morbidities such as HIV, diabetes etc.
  • Patients >65 years of age.

Click here to access the pdf.

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Standard Treatment Guidelines and Essential Medicines List for South Africa, Primary Healthcare, 2020-2024_Version 1.1_20 January 2025

Chapter 10: Infections and Related Conditions_10.7 Malaria_10.7.1 Malaria, non-severe/uncomplicated