Non-Severe Tuberculosis Disease
Indications Includes smear-negative pulmonary TB (low bacillary load) or with no more than mild to moderate lymph node enlargement and/or lung field opacification, or simple pleural effusion. See: https://theunion.org/sites/default/files/2022-03/The%20Union_Diagnostic%20Atlas%20for%20TB%20in%20Children_2022.pdf Dosing Adjust treatment dosages to current body weight. If calculating dosages,
Indications
Includes smear-negative pulmonary TB (low bacillary load) or with no more than mild to moderate lymph node enlargement and/or lung field opacification, or simple pleural effusion.
Dosing
- Adjust treatment dosages to current body weight.
- If calculating dosages, rather give ½ tablet more than ½ tablet less.
Children up to 8 years:
Dosing recommendations for dispersible combinations tablets:
| Pre-treatment body weight | 2 months intensive phase given daily | 2 months continuation phase given daily |
| RHZ | RH | |
|
75/50/150 mg dispersible tablet (scored) OR 75/50/150 mg per 4 mL solution* |
75/50 mg dispersible tablet (scored) OR 75/50 mg per 4 mL solution* |
|
| 2–2.9 kg | ½ tablet or 2 mL | ½ tablet or 2 mL |
| 3–3.9 kg | ¾ tablet or 3 mL | ¾ tablet or 3 mL |
| 4–7.9 kg | 1 tablet or 4 mL | 1 tablet or 4 mL |
| 8–11.9 kg | 2 tablets or 8 mL | 2 tablets or 8 mL |
| 12–15.9 kg | 3 tablets or 12 mL | 3 tablets or 12 mL |
| 16–24.9 kg | 4 tablets or 16 mL | 4 tablets or 16 mL |
Note:
Children should be taught and encouraged to swallow whole tablets or, if required, fractions of tablets so as to avoid large volumes of liquid medication. *If oral suspension required, for each dose, disperse 1 x RHZ 75/50/150 mg or 1 x RH 75/50 mg tablet in 4 mL of water, administer required dose, discard unused suspension.
Click on the table to enlarge
AND
- Pyridoxine, oral, daily for 6 months if HIV-infected, malnourished, or with existing neuropathy:
- Child < 5 years: 12.5 mg.
- Child ≥ 5 years: 25 mg.
Children > 8 years of age and adolescent (and > 25 kg):
| Pretreatment body weight | 2 months intensive phase given daily | 2 months continuation phase given daily | |
| RHZE (150, 75, 400, 275) |
RH (150, 75) |
RH (300, 150) |
|
| 25–37.9 kg | 2 tablets | 2 tablets | |
| 38–54.9 kg | 3 tablets | 3 tablets | |
| 55–70.9 kg | 4 tablets | 2 tablets | |
| > 71 kg | 5 tablets | 2 tablets | |
AND
- Pyridoxine, oral, daily for 6 months if HIV-infected, malnourished, or with existing neuropathy:
- Child < 5 years: 12.5 mg.
- Child ≥ 5 years: 25 mg.
Standard Treatment Guidelines And Essential Medicines List For South Africa, Hospital Level, Paediatrics, 2023 Edition
Chapter 10: Tuberculosis, 10.2 Tuberculosis, Pulmonary In Children, 10.2.1 Non-severe Tuberculosis Disease