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Pelvic Inflammatory Disease (PID)

Infection Pelvic Inflammatory Disease (PID) Brief outline/clinical setting Pelvic inflammatory disease (PID) comprises a spectrum of inflammatory disorders of the upper female genital tract. A PVD plus cervical motion tenderness/uterine tenderness/adnexal tenderness should be present Grading of PID (Gainesville) Grade I: Acute salpingitis without peritonitis Grade II: Acute salpingitis with perit

Infection Pelvic Inflammatory Disease (PID)
Brief outline/clinical setting

Pelvic inflammatory disease (PID) comprises a spectrum of inflammatory disorders of the upper female genital tract. A PVD plus cervical motion tenderness/uterine tenderness/adnexal tenderness should be present

Grading of PID (Gainesville)

Grade I: Acute salpingitis without peritonitis
Grade II: Acute salpingitis with peritonitis
Grade III: Acute salpingitis with tubo-ovarian complex or tubal occlusion
Grade IV: Ruptured tubo-ovarian complex and/or generalized peritonitis

Aetiologies/organisms

N. gonorrhoeae and C. trachomatis

Microorganisms that comprise the vaginal flora e.g., anaerobes, G. vaginalis, Haemophilus influenzae, enteric Gram-negative rods, and Streptococcus agalactiae) have been associated with PID

Optimal antimicrobial selection

Grade I

  • Ceftriaxone 1g IM stat (diluted in 0.9ml lidocaine 1%), plus Doxycycline 100 mg orally twice daily for 14 days, plus Metronidazole 400 mg orally twice daily for 14 days
  • Azithromycin 1G stat (repeated after 1 week) is an alternative to doxycycline.

Grade II-IV

  • May warrant admission for IV Antibiotics and possible surgical intervention
  • Consult Gynae Team if any clinical concerns ie. Fever, tachycardia etc. Q-Sofa score ≥ 1
  • Amoxicillin- clavulanate 1.2g 8hrly ivi

Second line Therapy:

  • Piperacillin - Tazobactam – ONLY In consultation with AMS Committee

On Discharge to complete a course of Metronidazole and Doxycycline for 7 days.

Duration As stated above
Alternative if allergic/not available Grade III-IV MUST be referred for Gynae review
Rationale
  

Level of evidence Moderate
link to Guideline Click here

CMJAH Antimicrobial Therapy Guideline - Community Acquired Infections Adult Emergency Department 2020

Drugs mentioned

NeoHealth® ID 23831 · updated 12/1/2021