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Periorbital Cellulitis

Infection Periorbital cellulitis Brief outline/clinical setting Approximately 3% of sinusitis cases will progress to orbital cellulitis, with 60–85% of orbital cellulitis cases being secondary to sinusitis. In the absence of abscess formation or reduction in visual signs medical management should initially be imple- mented for the first 24 hours, with frequent monitoring. If no significant clinic

Infection Periorbital cellulitis
Brief outline/clinical setting Approximately 3% of sinusitis cases will progress to orbital cellulitis, with 60–85% of orbital cellulitis cases being secondary to sinusitis. In the absence of abscess formation or reduction in visual signs medical management should initially be imple- mented for the first 24 hours, with frequent monitoring. If no significant clinical improvement in the first 24 hours of medical treatment , surgical intervention should be considered. If at any point there is any clinical deterioration, urgent repeat imaging with a view to emergency surgical intervention is required
Aetiologies/organisms S. pneumonia
S. anginosus and other Streptococcus species
H. influenzae
S. aureus
Moraxella catarrhalis
anaerobic bacteria (Prevotella, Porphyromonas, Fusobacterium and Peptostreptococcus species)
Optimal antimicrobial selection Ceftriaxone 1-2g IV BD 
plus
Metronidazole 500mg IVI TDS
Duration 14 days
Alternative if allergic/not available  
Rationale Sandwell and West Birmingham Hospitals NHS Trust
Level of evidence  
Link to Guideline Click here

Drugs mentioned

NeoHealth® ID 23880 · updated 3/27/2024