P.Falciparum Malaria, Non-Severe, Uncomplicated

Description

Medicine treatment

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ICD-10 code: B50.9

DESCRIPTION

A child with uncomplicated malaria is alert, can tolerate oral medication, has an age-appropriate level of consciousness and has no clinical or laboratory evidence of severe malaria.

Ideally, treatment should be started in hospital. Initial doses should be directly observed. Observe for 1 hour to ensure dose is not vomited.

MEDICINE TREATMENT

Treat according to the National Malaria Guidelines.

Option 1:

Only for clearly uncomplicated, low risk malaria cases (> 5 kg):

• Artemether/lumefantrine 20/120 mg, oral, with fat-containing food/milk to ensure adequate absorption.
  • Give first dose immediately.
  • Follow with second dose 8 hours later.
  • Then 12 hourly for another 2 days (total number of doses in 3 days = 6).

Weight	Dose	Total tablets per course
5–≤ 15 kg	1 tablet	6
15–≤ 25 k	2 tablets	12
25–≤ 35 kg	3 tablets	18
> 35 kg	4 tablets	24

OR
Option 2:

Manage children < 5 kg with uncomplicated malaria with quinine plus clindamycin:

• Quinine, oral, 10 mg/kg/dose 8 hourly for 7–10 days.

2–3 days after initiating treatment with quinine:

• Clindamycin, oral, 10 mg/kg/dose 12 hourly for 7 days.

Children who are vomiting but who have no other indications of severe malaria:

Children ≥ 20 kg:

• Artesunate, IM or IV, 2.4 mg/kg at hours 0, 12 and 24, then daily until patient is able to tolerate oral treatment.

Children < 20 kg:

• Artesunate, IM or IV, 3 mg/kg at hours 0, 12 and 24, then daily until patient is able to tolerate oral treatment.

Click here for the pdf.

Click here for Erratum-3. Reference: 2024/07/EDP/01.

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Standard Treatment Guidelines and Essential Medicines List for South Africa Paediatric Hospital _2023, 5th edition_Updated July 2024 
Chapter 8: Infective/Infectious Diseases,  8.9.1 P. Falciparum Malaria, Non-severe, Uncomplicated