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Prostatitis

Standard Treatment Guidelines and Essential Medicines List for South Africa, Hospital Level, Adults 2019 Edition

Description

Medicine treatment

Referral


N41.1/N41.9 + (N34.2)

DESCRIPTION

Clinical features include:

  • pyrexia,
  • acute pain in the pelvis and perineum,
  • dysuria and frequency,
  • urinary retention or difficulty, and
  • acutely tender prostate on rectal examination.

Chronic non-bacterial prostatitis
This is a diagnosis of exclusion, i.e. failure to respond to antibiotics. It is associated with perineal, suprapubic, penile and testicular pain.

MEDICINE TREATMENT

Acute bacterial prostatitis

If there are features of associated urethritis (STI regimen):

  • Ceftriaxone, IM, 250 mg as a single dose.

LoE:IIIbxxxvii

AND

  • Azithromycin, oral, 1 g as a single dose.

LoE:IIIbxxxviii

If there are no features of associated urethritis: 

  • Ciprofloxacin, oral, 500 mg 12 hourly for 14 days.

LoE:IVb

Chronic/relapse/persistent infection: N41.1

  • Ciprofloxacin, oral, 500 mg 12 hourly for 28 days.

LoE:IVb

REFERRAL

To urologist if:

  • No response to treatment.
  • Urinary retention present.
  • Chronic/relapsing prostatitis.

Click here to access the pdf.


Standard Treatment Guidelines and Essential Medicines List for South Africa, Adult Hospital Level, 2020-2024_Version 1.0_17 October 2024

Chapter 7 Nephrology/Urological Disorders_7.3 Urological Disorders_7.3.4 Prostatitis

Drugs mentioned

ICD-10 codes

NeoHealth® ID 17909 · updated 7/9/2025