GuidelinesOther guideline
Sepsis in an Adult with Recent Hospitalisation
Infection Sepsis in an adult with Recent hospitalisation Brief outline/clinical setting Patients with recent hospitalisation (<6 weeks prior) at higher risk of infection due to drug resistant pathogens Patient has signs of organ dysfunction and requires admission Aetiologies/organisms S.aureus, E.coli, K.pneumoniae, E.cloacae, Proteus spp, Enterococcus spp, These organisms may harbour resistan
| Infection | Sepsis in an adult with Recent hospitalisation |
|---|---|
| Brief outline/clinical setting | Patients with recent hospitalisation (<6 weeks prior) at higher risk of infection due to drug resistant pathogens Patient has signs of organ dysfunction and requires admission |
| Aetiologies/organisms | S.aureus, E.coli, K.pneumoniae, E.cloacae, Proteus spp, Enterococcus spp, These organisms may harbour resistance genes such as ESBL’s among Enterobacterales, or methicillin resistance among S.aureus |
| Optimal antimicrobial selection | Piperacillin- tazobactam Load with 4.5g IVI then 4.5g IVI QID + amikacin 15mg/kg IVI daily |
| Duration | Maximum 72 hrs- culture results should available in order to tailor therapy /alternative diagnosis made |
| Alternative if allergic/not available | Ertapenem 1g IVI bd according to local epidemiology- high incidence of ESBLs |
| Rationale | Local epidemiology and high rates of ESBL among HAI infections |
| Level of evidence | Moderate |