Sepsis in ICU - Introduction
ICD-10 code: A41.9 Definition Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunction is defined as an acute increase in SOFA (Sequential Organ Failure Assessment) score of at least 2 points. Patients with sepsis have a significantly higher mortality than those with an infection without sepsis. LoE:IVb liv Septic shock i
ICD-10 code: A41.9
Definition
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Organ dysfunction is defined as an acute increase in SOFA (Sequential Organ Failure Assessment) score of at least 2 points. Patients with sepsis have a significantly higher mortality than those with an infection without sepsis.
Septic shock is characterised by hypotension requiring vasopressors to maintain MAP ≥ 65mmHg despite adequate fluid resuscitation, plus a serum lactate >2mmol/l. Patients with septic shock have a significantly higher mortality (>20%) than those with sepsis without septic shock.
Adapted from: Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med. 1996;22:707–710
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Standard Treatment Guidelines and Essential Medicines List for South Africa Adult Hospital _Chapter 23: Adult Critical Care_NEMLC Medicine Recommendations Review Cycle_ 2020_2023