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Summary Points Pertaining to the Management of axSpA

Early diagnosis and prompt treatment initiation are essential in the management of axSpA, using the ASAS classification criteria as a reference. Both under-diagnosis and over-diagnosis are prevalent. Management by a rheumatologist-led multidisciplinary team should include pharmacological therapy, physical activity and referral to a patient support organisation. The goal of therapy is to achieve r

Early diagnosis and prompt treatment initiation are essential in the management of axSpA, using the ASAS classification criteria as a reference. Both under-diagnosis and over-diagnosis are prevalent. Management by a rheumatologist-led multidisciplinary team should include pharmacological therapy, physical activity and referral to a patient support organisation.
The goal of therapy is to achieve remission (ASDAS <1.3), or at least low disease activity (ASDAS <2.1). Sequential therapy should be offered until this goal is achieved.
Screening and management of comorbidities including cardiovascular disease, infections, osteoporosis and depression should be undertaken.

axSpA = axial spondyloarthritis; ASAS = Assessment of SpondyloArthritis International Society; ASDAS = ankylosing spondylitis disease activity score.

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Maharaj, A. B., et al. (2024). South African Rheumatism and Arthritis Association 2024 guidelines for the management of axial spondyloarthritis. South African Medical Journal, 114(10), e2668.

NeoHealth® ID 37379 · updated 3/12/2025