Neobook — clinical reference

Vaccine	Indication	Safety CD4+ count	Doses for unvaccinated adults	Booster	Comments
Measles, mumps, and rubella (MMR) vaccine	Measles, mumps or rubella seronegative	>200 cells/μL	2 doses (28 days apart)	Protection likely life-long	Mainly indicated in measles seronegative HIV-infected women of child bearing age Pregnancy should be avoided for 1 month after vaccination
Influenza	R	Any	1 dose	Yearly
Pneumococcal Conjugated (PCV-13)	R	Any	1 dose		Given with PPV-23 but must be given first
Pneumococcal Polysaccharide (PPV-23)	RS	>200 cells/μL	1 dose	5-10 years	Given with PCV-13 but given 8 weeks after PCV-13 Can be given to patients with CD4 count < 200 cells/μL if on ART and VL suppressed Maximum 2 booster doses, 1 booster dose in patients > 65 years. Poor response if CD4 cell count< 200 cells/μL and VL not suppressed
Hepatitis B	R	Any	4 doses (40 µg) or 3 doses (20 µg)	Not clear awaiting evidence
Hepatitis A	RS- travel, MSM, liver disease	>200 cells/μL	2 doses	10 years
Meningococcal	RS	Any	2 doses	5 years
Tetanus-diphtheria (Td)	R	Any		10 years
Pertussis- acellular	R	Any	1 doses	?10 years	Given in pregnancy combined with Tetanus- diphtheria (DTPa/dTpa)
Poliomyelitis- inactivated	RS	>200 cells/μL	3 doses	none
Human Papilloma virus (HPV)	RS- Females, MSM	Any	2 doses	none
Varicella	NR				May be considered if CD4 count >400 cells/μL
Zoster	RS	>200 cells/μL	1 doses	none	Only use if CD4 count ≥200 cells/µL