GuidelinesPrimary Care STG

Treatment of Partners

Sexually Transmitted Infections

Syndrome	Asymptomatic partner	Symptomatic partner
VDS	- Ceftriaxone, IM, 250 mg immediately as a single dose AND - Metronidazole, oral, 2 g immediately as a single dose AND - Azithromycin, oral, 1 g as a single dose	- Ceftriaxone, IM, 250 mg immediately as a single dose AND - Metronidazole, oral, 2 g immediately as a single dose AND - Azithromycin, oral, 1 g as a single dose PLUS treatment for syndrome present if not included in the above
LAP	- Ceftriaxone, IM, 250 mg immediately as a single dose AND - Metronidazole, oral, 2 g immediately as a single dose AND - Azithromycin, oral, 1 g as a single dose	- Ceftriaxone, IM, 250 mg immediately as a single dose AND - Metronidazole, oral, 2 g immediately as a single dose AND - Azithromycin, oral, 1 g as a single dose PLUS treatment for syndrome present if not included in the above
MUS	- Ceftriaxone, IM, 250 mg immediately as a single dose AND - Azithromycin, oral, 1 g as a single dose	- Ceftriaxone, IM, 250 mg immediately as a single dose AND - Azithromycin, oral, 1 g as a single dose PLUS treatment for syndrome present if not included in the above (see VDS flow chart)
Scrotal swelling	- Ceftriaxone, IM, 250 mg immediately as a single dose AND - Azithromycin, oral, 1 g as a single dose	- Ceftriaxone, IM, 250 mg immediately as a single dose AND - Azithromycin, oral, 1 g as a single dose PLUS treatment for syndrome present if not included in the above
GUS	- Doxcycyline, oral, 100 mg 12 hourly for 14 days Except pregnant women: - Benzathine benzylpenicillin, IM, 2.4 MU immediately as a single dose - Dissolve benzathine benzylpenicillin, IM, 2.4 MU in 6 mL lidocaine 1% without epinephrine (adrenaline) (If pregnant and benzathine benzylpenicillin is unavailable, see syphilis flow chart)	- Doxcycyline, oral, 100 mg 12 hourly for 14 days. Except pregnant women: - Benzathine benzylpenicillin, IM, 2.4 MU immediately as a single dose - Dissolve benzathine benzylpenicillin, IM, 2.4 MU in 6 mL lidocaine 1% without epinephrine (adrenaline) PLUS treatment for syndrome present if not included in the above (If pregnant and benzathine benzylpenicillin is unavailable, see syphilis flow chart)
Bubo	Azithromycin, oral, 1 g as a single dose	- Azithromycin, oral, 1 g as a single dose PLUS treatment for syndrome present if not included in the above

LoE:III²⁸⁰

Standard Treatment Guidelines and Essential Medicines List for South Africa, Primary Healthcare Level, 2024 Edition

Drugs mentioned