GuidelinesOther guideline
Tuberculosis
Infection Tuberculosis Brief outline/clinical setting Aetiologies/organisms Mycobacterium tuberculosis Optimal antimicrobial selection Drug Susceptible: Weight 30kg-37kg: - R/H/Z/E(150/75/400/275) 2 PO daily x 2 months - R/H (150/75) 2 PO daily x 4 months Weight 38kg-54kg: - R/H/Z/E(150/75/400/275) 3 PO daily x 2 months - R/H (150/75) 3 PO daily x 4 months Weight 55kg-70kg: - R/H/Z/E(150/7
| Infection | Tuberculosis |
| Brief outline/clinical setting | |
| Aetiologies/organisms | Mycobacterium tuberculosis |
| Optimal antimicrobial selection | Drug Susceptible: Weight 30kg-37kg: - R/H/Z/E(150/75/400/275) 2 PO daily x 2 months - R/H (150/75) 2 PO daily x 4 months Weight 38kg-54kg: - R/H/Z/E(150/75/400/275) 3 PO daily x 2 months - R/H (150/75) 3 PO daily x 4 months Weight 55kg-70kg: - R/H/Z/E(150/75/400/275) 4 PO daily x 2 months - R/H (300/150) 2 PO daily x 4 months Weight > 70kg: - R/H/Z/E(150/75/400/275) 5 PO daily x 2 months - R/H (300/150) 2 PO daily x 4 months Add Pyridoxine 25mg-75mg( max 200mg) PO daily - Prevent Peripheral Neuropathy ADD Steroids (decadron) for TB meningitis and TB pericarditis 8mg PO daily x 1 month (then wean over 2 weeks) Drug resistant TB: Refer to a TB centre Drug induced liver injury: Refer to a TB centre |
| Duration | 6 months For severe forms of TB( meningitis, miliary TB, bone and joint infection): Extend to 9 months (2 months intensive phase and 7 months continuation phase) |
| Alternative if allergic/not available | |
| Rationale | |
| Level of evidence | High |
| Link to Guideline | SA National TB guidelines Click here |