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Type 1 Diabetes Mellitus

Endocrine Conditions

Description 

Clinical Presentation

Diagnosis

General Measures 

Referral


DESCRIPTION

  • Type 1 diabetes mellitus, previously known as juvenile onset diabetes mellitus and as insulin-dependent diabetes mellitus (IDDM), occurs because of a lack of insulin. The result is an increase in blood glucose concentration

CLINICAL PRESENTATION

  • Hunger
  • Polyuria
  • Ketoacidosis
  • Thirst
  • Unexplained weight loss
  • Tiredness

DIAGNOSIS

Type 1 diabetes mellitus is diagnosed when the classic symptoms of polyuria and polydipsia are associated with hyperglycaemia:

  • Random plasma glucose ≥11.1 mmol/L
  • Random is defined as any time of day without regard to time since last meal

OR

  • Fasting plasma glucose ≥7.0 mmol/L
  • Fasting is defined as no caloric intake for ≥8 hours

OR

  • 2-hour plasma glucose in a 75 g oral glucose tolerance test ≥11.1 mmol/l

LoE:III171

GENERAL MEASURES

  • Education regarding diabetes and its complications
  • Even and regular meal consumption
  • Dietary emphasis should be on regulating carbohydrate, fibre and fat intake (See: Diabetes mellitus, in adults for recommended diet plan)
  • Increased physical activity, aim for 30 minutes 5 times a week
  • Appropriate weight loss if body mass index >25 kg/m2
  • Education about foot care
  • Monitor for development of depression
  • All patients should wear a notification bracelet

REFERRAL

  • All patients

Standard Treatment Guidelines and Essential Medicines List for South Africa, Primary Healthcare Level, 2024 Edition

NeoHealth® ID 18305 · updated 8/12/2025