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GuidelinesOther guideline

Uncomplicated UTI

Infection Uncomplicated UTI Brief outline/clinical setting Community acquired organisms are becoming increasingly resistant and where possible a culture should be performed prior to therapy. Cultures should be performed always: Where symptoms persist When antibiotics have been administered in the last 3 months Symptoms with negative dipstix for nitrites or leucocyte esterase Aetiologies/organisms

Infection Uncomplicated UTI
Brief outline/clinical setting

Community acquired organisms are becoming increasingly resistant and where possible a culture should be performed prior to therapy. Cultures should be performed always:

  • Where symptoms persist
  • When antibiotics have been administered in the last 3 months

Symptoms with negative dipstix for nitrites or leucocyte esterase

Aetiologies/organisms

Enterobacterales: E. coli, K. pneumoniae, Enterobacter spp, Proteus spp S. saprophyticus, Group B streptococcus, Enterococcus spp.

Optimal antimicrobial selection

Cefuroxime: 1.0 gram BD x 3-5 days; (level of evidence 3; recommendation grade: strong)
Cephalexin: 500mg q6h PO x 3-5 days; (level of evidence 3; recommendation grade: moderate)
Nitrofurantoin 100 mg, twice daily x 3-5 days (level of evidence2; recommendation grade: strong)
Amoxicillin: 1 gram BD: (level of evidence 3; recommendation grade: strong)

Duration Dependent on agent used (see above)
Alternative if allergic/not available Fosfomycin: 3 grams stat and 3 grams on the third day (Level of evidence 2; recommendation grade: strong)
Amoxicillin/clavulanate 1 gram BD: (level of evidence 3; recommendation grade: strong)
Rationale
  

Level of evidence See above

Drugs mentioned

NeoHealth® ID 23837 · updated 3/27/2024