Aluminium/ Magnesium

Registered South African indications:

• Gastric acidity
• Dyspepsia
• Gastritis
• Peptic ulcers
• Oesophageal reflux

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Aluminium
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Hypophosphataemia
• Acute porphyria

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment

Magnesium
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Severe renal impairment (Magnesium trisilicate)
• Hypophosphataemia(Magnesium trisilicate)

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Prolonged use
• Sodium restricted diet
• Magnesium restricted diet
• Neuromuscular disease
• Hypermagnesaemia
• Heart failure
• Hypertension
• Metabolic alkalosis
• Respiratory alkalosis

Forms avail. in SA and covered in this monograph: sus, tab

Gastric acidity
Dyspepsia
Gastritis
Peptic ulcers
Oesophageal reflux 

Aluminium/ Magnesium
282/120 (mg/15ml)

• Oral (sus): 10-15ml, 1-3 hours after meals and at bedtime; Max treatment duration: 2 weeks

225/200 (mg/5ml)

• Oral (sus): 10-20ml, 30min to 1 hr after meals and at bedtime; Max: 80ml/24hrs

Bottle must be shaken before use

Aluminium/ Magnesium
250/500 (mg)

• Oral (tab): 1-2 tabs, 3-6hrly; Max: 16 tabs/24hrs; Max duration: 2 weeks

Chew or allow tablet to disintegrate in the mouth

Not established for use in children below 12 years

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• Caution (Magnesium hydroxide)
  Refer to single agent monograph for Aluminium
  Refer to single agent monograph for Magnesium trisilicate
  Refer to single agent monograph for Magnesium hydroxide   

Breastfeeding

• Compatible (Aluminium, Magnesium)
  Refer to single agent monograph for Aluminium
  Refer to single agent monograph for Magnesium trisilicate
  Refer to single agent monograph for Magnesium hydroxide 

Renal Impairment

• Mild to moderate: Caution; no dose adjustment recommended (Aluminium, Magnesium)
• Severe: Contraindicated (Magnesium trisilicate)
  Refer to single agent monograph for Aluminium
  Refer to single agent monograph for Magnesium trisilicate
  Refer to single agent monograph for Magnesium hydroxide  

Hepatic Impairment

• Caution; no dose adjustment recommended (Magnesium trisilicate)
  Refer to single agent monograph for Aluminium
  Refer to single agent monograph for Magnesium trisilicate 
  Refer to single agent monograph for Magnesium hydroxide  

Elderly

• Caution; no dose adjustment recommended (Aluminium)
  Refer to single agent monograph for Aluminium
  Refer to single agent monograph for Magnesium trisilicate
  Refer to single agent monograph for Magnesium hydroxide  

Porphyria Information

• Not porphyrinogenic (NP)

Drugs in Sport

• Permitted - No warnings

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Aluminium
Gastrointestinal Disorders

• Constipation

Magnesium
Gastrointestinal Disorders

• Diarrhoea

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Aluminium

• Tetracyclines
• Penicillin
• Sulphonamides
• Iron
• Digoxin
• Non-steroidal anti-inflammatory drugs 
• Vitamins

Magnesium

• Alfacalcidol
• Alpha-lipoic acid
• Bisphosphonates
• Calcitriol
• Calcium polystyrene sulfonate
• Sodium polystyrene sulfonate
• Deferiprone
• Dolutegravir
• Doxercalciferol
• Eltrombopag
• Gabapentin
• Levothyroxine
• Fluoride
• Mycophenolate
• Phosphate supplements
• Quinolones
• Raltegravir
• Tetracyclines
• Trientine

None routine. Specific cases may require

• Serum calcium
• Serium phosphate

Aluminium
Aluminium hydroxide reacts chemically to neutralize or buffer existing quantities of stomach acids but has no direct effects on its production. The action increases gastric pH, providing symptomatic relief of hyperacidity.

Magnesium
Magnesium is the second most abundant cation in intracellular fluid and is an essential body electrolyte. It is a factor in a number of enzyme systems and is involved in neurochemical transmission and muscular excitability.

Aluminium/ Magnesium is available in several formulations. Please note the list below gives examples of products which are available and is not necessarily comprehensive. The listing of a product does not constitute endorsement of the product by EMGuidance; likewise, failure to list a product does not imply that EMGuidance disapproves of the product. This information is put together on the basis of the National Government's Medicines Price Registry at the time of publication.

COMBINATION PREPARATIONS

Aluminium/ Magnesium

Suspension (per 15ml) 282mg/120mg

• Adco-Mayogel (Adcock)

Suspension (per 5ml) 225mg/200mg

• Maalox (Sanofi)

Tablet 250mg/500mg

• Aciban (Be-Tabs)
• Gelusil Peppermint (Pharma Dynamics)