Calcium Carbonate/ Magnesium Carbonate

Registered South African indications:

• Heartburn
• Indigestion

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Calcium carbonate
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Hypercalcaemia
• Hyperparathyroidism 
• Hypercalciuria
• Nephrolithiasis
• Zollinger-Ellison Syndrome
• Low phosphate diet
• Coadministration with cardiac glycosides

Cautions

• Pregnancy
• Renal impairment
• Diabets mellitus

Magnesium carbonate
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product

Cautions

• Pregnancy
• Renal impairment
• Myasthenia gravis or other neuromuscular disease
• High doses

Additional contraindications for this combination product

• Hypermagnesaemia
• Alkalosis

Forms avail. in SA and covered in this monograph: chu

When an antacid is indicated
- Heartburn
- Indigestion
- Pregnancy

Calcium carbonate/ Magnesium carbonate
680/80 (mg)

• Oral (chu): 1-2 tab, every 30min as required; Max: 12 tab/24hrs

Chewable tablet can be sucked or chewed

Paed. forms avail. in SA and covered in this monograph: chu

When an antacid is indicated
- Heartburn
- Indigestion

Calcium carbonate/ Magnesium carbonate
680/80 (mg)

Younger than 5 years

• Not established for use

Between 5-8 years

• Oral (chu): 1/2-1 tab, every 30min as required; Max: 4 tab/24hrs

Between 8-12 years

• Oral (chu): 1-2 tab, every 30min as required; Max: 8 tab/24hrs

Older than 12 years

• See adult dosage

Chewable tablet can be sucked or chewed

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• Caution (Magnesium carbonate)
• Magnesium crosses the placenta; serum concentrations in the fetus are similar to those in the mother. Magnesium carbonate is only recommended for use during pregnancy when benefit outweighs risk
• Data on a large number of exposed pregnancies indicate no adverse effects of calcium carbonate tablets on pregnancy or on the health of the fetus/newborn child. To date no other epidemiological date are available

Breastfeeding

• Compatible (Calcium carbonate, Magnesium carbonate)
• No problems are anticipated when using this product during lactation
• Magnesium is found in breast milk, concentrations remain constant during the first year of lactation and are not influenced by dietary intake under normal conditions. Magnesium requirements are the same in lactating and nonlactating females

Renal Impairment

• Caution; dose adjustment recommended (Calcium carbonate)

Hepatic Impairment

• No dose adjustment recommended (Calcium carbonate, Magnesium carbonate)

Elderly

• No dose adjustment recommended (Calcium carbonate, Magnesium carbonate)

Porphyria Information

• Not yet classified (NC) (Magnesium carbonate)

Drugs in Sport

• Non-regulated product: Authorities caution athletes against the risk of using these products

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Calcium carbonate
Gastrointestinal Disorders

• Constipation 
• Flatulence
• Rebound acidity

Endocrine and Metabolic Disorders

• Hypercalcaemia 
• Alkalosis
• Milk-alkali syndrome

Magnesium carbonate

• No information available

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Calcium carbonate

• Tetracyclines
• Bisphosphonates
• Thiazide diuretics

Magnesium carbonate

• Alfacalcidol
• Allopurinol
• Alpha-lipoic acid
• Atazanavir
• Bisacodyl
• Bismuth subcitrate
• Bisphosphonate derivatives
• Bosutinib
• Calcitriol
• Calcium polystyrene sulfonate
• Cefditoren
• Cefuroxime
• Chloroquine
• Corticosteroids
• Dabigatran etexilate
• Dasatinib
• Deferiprone
• Delavirdine
• Dolutegravir
• Doxercalciferol
• Eltrombopag
• Elvitegravir
• Erlotinib
• Fexofenadine
• Fosinopril
• Gabapentin
• Gefitinib
• Hyoscyamine
• Iron salts
• Isoniazid
• Itraconazole
• Ketoconazole
• Lanthanum
• Ledipasvir
• Levothyroxine
• Mesalamine
• Methenamine
• Misoprostol
• Multivitamins
• Mycophenolate
• Neratinib
• Nilotinib
• Pazopanib
• Penicillamine
• Phosphate supplements
• Potassium phosphate
• Quinine
• Quinolones
• Raltegravir
• Rilpivirine
• Riociguat
• Sodium polystyrene sulfonate
• Sotalol
• Sulpiride
• Tetracyclines
• Trientine
• Velpatasvir

None routine

Calcium carbonate
Calcium carbonate reacts chemically to neutralise or buffer existing quantities of stomach acid but has no direct effect on its output. This action results in an increased pH of the stomach contents, thus providing relief of hyperacidity symptoms. It also reduces acid concentrations within the lumen of the oesophagus, thus causing an increase in intra-oesophageal pH and a decrease in pepsin activity, which aids the control of gastro-oesophageal reflux. 

Magnesium carbonate
Magnesium carbonate neutralises excess acid in the stomach by reacting with gastric hydrochloric acid to form magnesium chloride and carbon dioxide. 

Calcium carbonate/ Magnesium carbonate is available in several formulations. Please note the list below gives examples of products which are available and is not necessarily comprehensive. The listing of a product does not constitute endorsement of the product by EMGuidance; likewise, failure to list a product does not imply that EMGuidance disapproves of the product. This information is put together on the basis of the National Government's Medicines Price Registry at the time of publication.

COMBINATION PREPARATION

Calcium carbonate/ Magnesium carbonate

Tablet chewable 680mg/80mg

• Rennie Aniseed
• Rennie orange
• Rennie Peppermint
• Rennie Speartmint