Indinavir

Registered South African indications:

• HIV infection

Contraindications

• Hypersensitivity to the active ingredient or to any of its excipients
• Coadministration with alfuzosin, amiodarone, ergot derivatives, lovastatin, simvastatin, cisapride, lurasidone, pimozide, midazolam, triazolam, alprazolam, sildenafil, atazanavir, rifampicin and St John's wort

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Hepatic impairment
• Underlying infections
• Underlying autoimmune conditions
• Diabetes mellitus
• Haemophilia A or B

Forms avail. in SA and covered in this monograph: cap

HIV infection
- General dosing

• Oral (cap): 800mg, 8hrly

HIV infection
- In combination itraconazole, ketaconazole, delavirdine

• Oral (cap): 600mg, 8hrly

HIV infection
- In combination with rifabutin, efavirenz

• Oral (cap): 1000mg, 8hrly

To take with liquid on an empty stomach

Not established for use in children below 18 years in South Africa

Pregnancy

• FDA Pregnancy Category C

Breastfeeding

• Caution

Renal Impairment

• Caution; no information available

Hepatic Impairment 

• Mild to moderate: Caution; dose adjustment recommended 
• Severe: Caution; no information available 

Elderly

• No dose adjustment recommended

Central Nervous System Disorders

• Headache
• Dizziness
• Insomnia
• Hypoaesthesia
• Paraesthesia
• Oral paraesthesia

Gastrointestinal Disorders

• Nausea and vomiting 
• Diarrhoea
• Dyspepsia
• Flatulence
• Dry mouth
• Acid regurgitation
• Hepatitis
• Hepatic failure
• Pancreatitis

Genitourinary Disorders

• Haematuria
• Proteinuria
• Crystalluria
• Nephrolithiasis
• Dysuria
• Nephrolithiasis
• Pyelonephritis
• Interstitial nephritis
• Indinavir crystal deposits
• Renal insufficiency
• Renal failure 
• Leucocyturia

Endocrine and Metabolic Disorders

• New onset diabetes mellitus or hyperglycaemia
• Exacerbation of pre-existing diabetes mellitus
• Hypertriglyceridaemia
• Hypercholesterolaemia

Skin and Subcutaneous Tissue Disorders

• Rash
• Dry skin
• Pruritus
• Erythema multiforme 
• Stevens Johnson syndrome
• Hypersensitivity vasculitis
• Alopecia
• Hyperpigmentation
• Urticaria
• Ingrown toenails
• Paronychia

Immune, Blood and Lymphatic System Disorders

• Increase in mean corpuscular volume
• Decreased neutrophils
• Increased spontaneous bleeding in patients with haemophilia
• Acute haemolytic anaemia
• Thrombocytopenia
• Anaphylactoid reactions

• CYP3A4 inhibitors
• Alfuzosin
• Aliretinoin
• Almotriptan
• Alprazolam
• Amiodarone
• Aprepitant
• Aripiprazole
• Astemizole
• Asunaprevir
• Atorvastatin
• Avanafil
• Axitinib
• Barnidipine
• Bedaquiline
• Blonanserin
• Boceprevir
• Bosentan
• Bosutinib
• Brexpiprazole
• Brigatinib
• Bromocriptine
• Budesonide
• Calcium channel blockers
• Carbamazepine
• Ceritinib
• Cilostazol
• Cisapride
• Clarithromycin
• Colchicine
• Ciclosporin
• CYP3A4 inducers
• CYP3A4 substrates
• Dapoxetine
• Didanosine
• Domperidone
• Doxorubicin
• Efavirenz
• Eletriptan
• Eplerenone
• Ergot derivatives
• Everolimus
• Fentanyl
• Fluticasone
• Garlic
• Halofantrine
• Hydroxyzine
• Itraconazole
• Ivabradine
• Ketoconazole
• Lercanidipine
• Lomitapide
• Lovastatin
• Maraviroc
• Methylprednisolone
• Midazolam
• Mifepristone
• Nefazodone
• Nevirapine
• Oxycodone
• Pimozide
• Protease inhibitors
• Quetiapine
• Ranolazine
• Rifabutin
• Rifampicin
• Rosuvastatin
• Rupatadine
• Salmeterol
• Saxagliptin
• Sildenafil
• Simvastatin
• St John's wort
• Sufentanil
• Tacrolimus
• Tadalafil
• Tamsulosin
• Terfenadine
• Ticagrelor
• Trazodone
• Triazolam
• Vincristine
• Zopiclone
• Zuclopenthixol

• Serum lipids
• Blood glucose
• Liver function tests
• Full blood count

Specific cases may require

• Urinalysis

Indinavir inhibits the HIV viral protease enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.

Capsule 400mg

• Crixivan (MSD) originator (Discontinued: 11/06/2018)