Nicotinamide

Registered South African indications:

• Nicotinamide deficiency

Contraindications

• Hypersensitivity to the active ingredient or any of the excipients

Cautions

• Pregnancy
• Breastfeeding 
• Hepatic impairment
• Diabetes mellitus
• Gout
• History of peptic ulcer disease

Forms avail. in SA and covered in this monograph: tab

Nicotinic acid deficiency - Severe
Pellegra

• Oral (tab): 100mg, 8hrly; Treatment duration: 1 week

Nicotinic acid deficiency - Mild

• Oral (tab): 100mg, dly; Treatment duration: 1 week

Take with food or milk

Paed. forms avail. in SA and covered in this monograph: tab

Nicotinic acid deficiency - Severe
Pellegra

• Oral (tab): 50mg, 8hrly; Treatment duration: 1 week

Nicotinic acid deficiency - Mild 

• Oral (tab): 50mg, dly; Treatment duration: 1 week

Take with food or milk

Pregnancy

• FDA Pregnancy Category Not Rated (NR) 

Breastfeeding

• Caution 

Renal Impairment

• No dose adjustment recommended

Hepatic Impairment

• Caution; no dose adjustment recommended

Elderly

• No dose adjustment recommended

Porphyria Information

• Not yet classified (NC)

Central Nervous System Disorders

• Fainting
• Headache
• Dizziness

Cardiovascular Disorders

• Flushing

Gastrointestinal Disorders

• Abdominal pain
• Diarrhoea
• Nausea and vomiting

Hepatobiliary Disorders

• Jaundice
• Increased hepatic enzymes
• Hepatotoxicity

Endocrine and Metabolic Disorders

• Hyperglycaemia

Skin and Subcutaneous Tissue Disorders

• Rash

Immune, Blood and Lymphatic System Disorders

• Hypersensitivity reactions

Sensory Disorders

• Blurred vision

• HMG-CoA reductase inhibitors
• Antidiabetic agents
• Primidone
• Carbamazepine

None routine

Nicotinamide is a water-soluble component of the vitamin B complex group. It functions as a component of the coenzyme nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. It is involved in proper utilisation of fats, healthy skin, nerves, digestive system, blood vessels and cholesterol control. It is also essential for the synthesis of sex hormones.

Nicotinamide is available in several formulations. Please note the list below gives examples of products which are available and is not necessarily comprehensive. The listing of a product does not constitute endorsement of the product by EMGuidance; likewise, failure to list a product does not imply that EMGuidance disapproves of the product. This information is put together on the basis of the National Government's Medicines Price Registry at the time of publication

Tablet 100mg

• Be-Tabs Nicotinamide (Be-Tabs)   
• Portfolio Nicotinamide (Portfolio)