GuidelinesOther guideline
Renal Dose Adjustments in Adults
Drug dosing for children with renal impairment should be discussed with experienced clinicians. The table below refers to adults. Drug Recommended dose and frequency for adults with creatinine clearance <30 ml/min or for patients receiving haemodialysis (unless otherwise indicated dose after dialysis) Bedaquiline No dosage adjustment is required in patients with mild to moderate renal impairme
Drug dosing for children with renal impairment should be discussed with experienced clinicians. The table below refers to adults.
| Drug | Recommended dose and frequency for adults with creatinine clearance <30 ml/min or for patients receiving haemodialysis (unless otherwise indicated dose after dialysis) |
| Bedaquiline | No dosage adjustment is required in patients with mild to moderate renal impairment (dosing not established in severe renal impairment, use with caution) |
| Linezolid | No adjustment necessary |
| Levofloxacin | 750-1000 mg per dose three times per week (not daily) |
| Moxifloxacin | No adjustment necessary |
| Clofazimine | No adjustment necessary |
| Terizidone | - 250 mg once daily or - 500 mg three times per week (not daily) |
| Delamanid | No dosage adjustment is required in patients with mild to moderate renal impairment (dosing not established in severe renal impairment, use with caution) |
| Pretomanid | No dosage adjustment is required |
| Ethambutol | 15-25 mg/kg per dose three times per week (not daily) |
| Pyrazinamide | 25-35 mg/kg per dose three times per week (not daily) |
| Imipenem-cilastatin (given with amoxicillin-clavulanate) | - Imipenem: for creatinine clearance 20-40 ml/min dose 500 mg every 8 hours; for creatinine clearance <20 ml/min dose 500 mg every 12 hours - Amoxicillin-clavulanate: 250 mg / 125 mg given 30 minutes prior to Imipenem |
| Meropenem (given with amoxicillin-clavulanate) | - Meropenem: 1000 mg every 12 hours; for creatinine clearance <10 ml/min dose 1000 mg once daily. - Amoxicillin-clavulanate: 250 mg / 125 mg given 30 minutes prior to Imipenem. |
| Ertapenem (given with amoxicillin-clavulanate) | - Ertapenem: 500 mg once daily - Amoxicillin-clavulanate: 250 mg / 125 mg given 30 minutes prior to Imipenem |
| Isoniazid | No adjustment necessary |
| Ethionamide | No adjustment necessary |
| Para-aminosalicylic acid | 4 g/dose, twice daily maximum dose |
| Amikacin | Stop amikacin, or if considered essential to treatment administer only with therapeutic drug monitoring |
| Rifabutin | No adjustment necessary |
National Department of Health Clinical Management of Rifampicin-Resistant Tuberculosis, September 2023
Renal Dose Adjustments in Adults