Terizidone

Registered South African indications:

• Drug resistant tuberculosis 

Contraindications

• Hypersensitivity to the active ingredient or any of the excipients

Cautions

• Pregnancy
• Renal impairment
• Seizure disorder
• Psychotic disease  
• Alcohol abuse

Forms avail. in SA and covered in this monograph: cap

Multidrug resistant tuberculosis (MDR TB)- intensive phase (in combination with other medication)

• Oral (cap): Less than 33kg: 15-20mg/kg, dly; Treatment duration: 6 months
• Oral (cap): Between 33-70kg: 750mg, dly; Treatment duration: 6 months
• Oral (cap): Greater than 70kg: 750-1000mg, dly; Treatment duration: 6 months
  Refer to Multidrug resistant tuberculosis: TB Guidelines, 2015

Multidrug resistant tuberculosis (MDR TB)- continuation phase (in combination with other medication)

• Oral (cap): Less than 33kg: 15-20mg/kg, dly; Treatment duration: 18 months
• Oral (cap): Between 33-70kg: 750mg, dly; Treatment duration: 18 months
• Oral (cap): Greater than 70kg: 750-1000mg, dly; Treatment duration: 18 months
  Refer to Multidrug resistant tuberculosis: TB Guidelines, 2015

Extremely drug resistant tuberculosis  (XDR  TB)- intensive phase (in combination with other medication)

• Oral (cap): Less than 33kg: 15-20mg/kg, dly; Treatment duration: 6 months
• Oral (cap): Between 33-50kg: 500mg, dly; Treatment duration: 6 months
• Oral (cap): Between 51-70kg: 750mg, dly; Treatment duration: 6 months
• Oral (cap): Greater than 71kg: 750-1000mg, dly; Treatment duration: 6 months
  Refer to extremely drug resistant tuberculosis: TB Guidelines, 2015

Extremely drug resistant tuberculosis  (XDR  TB)- continuation phase (in combination with other medication)

• Oral (cap): Less than 33kg: 15-20mg/kg, dly; Treatment duration: 18 months
• Oral (cap): Between 33-50kg: 500mg, dly; Treatment duration: 18 months
• Oral (cap): Between 51-70kg: 750mg, dly; Treatment duration: 18 months
• Oral (cap): Greater than 71kg: 750-1000mg, dly; Treatment duration: 18 months
  Refer to extremely drug resistant tuberculosis: TB Guidelines, 2015

Paed. forms avail. in SA and covered in this monograph: cap

Drug resistant tuberculosis (in combination with other medication)

• Oral (cap): 10-20mg/kg, dly; Max: 1g/24hrs
  Refer to TB Guidelines, 2015

Decisions related to dose adjustment/discontinuing TB regimen must be discussed in advance with Pulmonologists/Infectious Disease specialists, and cases must be dealt with individually

Pregnancy

• FDA Pregnancy Category Not Rated (NR)

Breastfeeding

• Compatible

Renal Impairment

• Caution; dose adjustment recommended 

Hepatic Impairment

• No dose adjustment recommended

Elderly

• No dose adjustment recommended

Porphyria Information

• Not yet classified (NC)

Drugs in Sport

• Permitted - No warning

Central Nervous System Disorders

• Headache
• Dizziness
• Tremor
• Dysarthria
• Convulsions
• Mania
• Depression
• Psychosis
• Suicidal ideation
• Central nervous system toxicity
• Inability to concentrate
• Lethargy
• Peripheral neuropathy

Gastrointestinal Disorders

• Gastrointestinal irritation

Skin and Subcutaneous Tissue Disorders

• Lichenoid eruption
• Stevens-Johnson syndrome

• Ethionamide  
• Isoniazid  
• Phenytoin
• Oral anticoagulants
• Pyridoxine
• Anticonvulsants  
• Neuroleptics
• Fluoroquinolones
• Alcohol

None routine. Specific cases may require

• Mental status

Terizidone is a cycloserine derivative. It is bacteriostatic and inhibits mycobacterial cell wall synthesis by interfering with peptidoglycan pentapeptide production

Capsule 250mg

• Terivalidin (Sanofi)
• Terizidone Macleods ( Macleods Pharmaceuticals)