Aluminium/ Magnesium/ Dicyclomine/ Simethicone

Registered South African indications:

• Peptic ulceration
• Gastritis
• Hyperacidity
• Dyspepsia
• Flatulence

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Aluminium
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Hypophosphataemia
• Acute porphyria

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment

Magnesium
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product

Cautions

• Pregnancy
• Breastfeeding
• Renal impairment
• Prolonged use
• Sodium restricted diet
• Magnesium restricted diet
• Neuromuscular disease

Dicyclomine
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product
• Breastfeeding

Cautions

• Renal impairment
• Hepatic impairment
• Elderly
• Glaucoma
• Prostatic hypertrophy
• Reflux oesophagitis secondary to hiatus hernia

Simethicone
Contraindications

• Hypersensitivity to the active ingredient or any of the excipients in this combination product

Cautions

• Neonates

Forms avail. in SA and covered in this monograph: sus

Peptic ulceration
Gastritis
Hyperacidity
Dyspepsia
Flatulence

Aluminium/ Magnesium/ Dicyclomine/ Simethicone
200/200/5/40 (mg/10ml)

• Oral (sus): 10-20ml, 6-8hrly

Paed. forms avail. in SA and covered in this monograph: sus

Peptic ulceration
Gastritis
Hyperacidity
Dyspepsia
Flatulence

Aluminium/ Magnesium/ Dicyclomine/ Simethicone
200/200/5/40 (mg/10ml)

• Younger than 2 years: Not established for use
• Between 2-12 years: 5-10ml, 8 hrly
• Older than 12 years: See adult dosage

Recommendations for this combination product as per highest risk category when comparing individual active ingredients

Pregnancy

• Caution; not recommended

Breastfeeding

• Contraindicated (Dicyclomine)

Renal Impairment

• Caution; no dose adjustment recommended (Aluminium, Magnesium, Dicyclomine)

Hepatic Impairment

• Caution; no dose adjustment recommended (Dicyclomine)

Elderly

• Caution; no dose adjustment recommended (Dicyclomine)

Drugs in Sport

• Permitted - No warning

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

Aluminium
Gastrointestinal Disorders

• Constipation

Magnesium
Gastrointestinal Disorders

• Diarrhoea

Dicyclomine
Central Nervous System Disorders

• Headache
• Dizziness
• Fatigue
• Sedation

Gastrointestinal Disorders

• Dry mouth
• Constipation
• Anorexia
• Nausea and vomiting

Genitourinary Disorders

• Dysuria

Skin and Subcutaneous Tissue Disorders

• Rash

Sensory Disorders

• Blurred vision

Simethicone

• No information available

Combination products may have additional pharmacological effects not accounted for by the action of the individual ingredients

 Aluminium

• Tetracyclines
• Penicillin
• Sulphonamides
• Iron
• Digoxin
• Nonsteroidal anti-inflammatory drugs 
• Vitamins

Magnesium

• Alfacalcidol
• Alpha-lipoic acid
• Bisphosphonates
• Calcitriol
• Calcium polystyrene sulfonate
• Sodium polystyrene sulfonate
• Deferiprone
• Dolutegravir
• Doxercalciferol
• Eltrombopag
• Gabapentin
• Levothyroxine
• Fluoride
• Mycophenolate
• Phosphate supplements
• Quinolones
• Raltegravir
• Tetracyclines
• Trientine

Dicyclomine

• Anticholinergic agents
• Glucagon
• Levosulpiride
• Potassium chloride
• Potassium citrate
• Secretin

Simethicone

• No information available

None routine. Specific cases may require

• Serum calcium
• Serium phosphate

Aluminium
Aluminium hydroxide is a basic inorganic salt that neutralises gastric hydrochloric acid and thus has an antacid effect. It also inhibits the actions of pepsin by decreasing the acidity of the stomach

Magnesium
Magnesium is the second most abundant cation in intracellular fluid and is an essential body electrolyte. It is a factor in a number of enzyme systems, and is involved in neurochemical transmission and muscular excitability

Dicyclomine
Dicyclomine relieves smooth muscle spasm of the gastrointestinal tract. It has antimuscarinic effects on acetylcholine receptors and also has a direct effect on smooth muscle

Simethicone (Dimethylpolysiloxane) 
Dimethylpolysiloxane acts by decreasing the surface tension in gas bubbles. In this way it prevents gas build-up in the gastrointestinal system

COMBINATION PREPARATIONS

Aluminium/ Magnesium/ Simethicone/ Dicyclomine

Suspension (per 10ml) 200mg/200mg/40mg/5mg

• Adco-Medigel (Adcock)