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DrugsLevel 4 LocalisationS1CREEML

Miconazole

ImidazoleAntifungal

Indications

These indications are based on manufacturer information for both originator and generic products. For product specific registered indications, please refer to product ) specific manufacturer information

Registered South African indications: 

  • Dermatomycoses
    - Tinea pedis (athlete's foot)
    - Tinea corporis (tinea circinata)
    - Tinea manuum
  • Tinea cruris due to
    - Trichophyton mentagrophytes
    - Trichophyton rubrum
    - Microsporum audouin
    - Epidermophyton floccosum
  • Candidial infections
    - Infections of the skin (.e.g. intertrigo)
    - Perianal infections
    - Stomatitis angularis (cheilitis, perleche)
    - Balanoposthitis

Contraindications (ZA)

Registered South African contraindications

  • Hypersensitivity to the active ingredient or any of its excipients

Warnings & precautions

South African recommendations

Caution in the following patient groups

  • Pregnancy
  • Breastfeeding
  • Renal impairment
  • Hepatic impairment
  • Elderly

Sensitivity or irritation

  • If a reaction suggesting sensitivity or irritation should occur, the treatment should be discontinued

Contact with eyes

  • Miconazole cream must not come into contact with the eyes

Effects on ability to drive and use machines

  • Not applicable

Adult dosage (ZA)

Forms avail. in SA and covered in this monograph: cre

South African registered indications and dosages

Infections caused by: Fungistatic against all Phycomycetes, Ascomycetes and Adelomycetes tested (e.g. Saprolegnia, Candida, Cryptococcus, Aspergillus, Dermatophytes, Phialophora, Sporotrichum) and fungicidal against Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Trichophyton interdigitale and Microsporum canis

Specific doses based on individual indications

Please note that the dosages below should be used in combination with regional guidelines, taking into account local antibiotic sensitivities

Dermatomycoses
- Tinea corporis (tinea circinata)
- Tinea manuum

Tinea cruris due to
- Trichophyton mentagrophytes
- Trichophyton rubrum
- Microsporum audouin
- Epidermophyton floccosum

Candidial infections
- Infections of the skin (.e.g. intertrigo)
- Perianal infections
- Stomatitis angularis (cheilitis, perleche)
- Balanoposthitis

  • Topical (cre): Apply to affected area(s), twice dly (morning and evening); Treatment duration: 2 weeks

Dermatomycoses
- Tinea pedis (athlete's foot)

  • Topical (cre): Apply to affected area(s), twice dly (morning and evening); Treatment duration: 1 month

Avoid occlusive dressings when this medication is used in the treatment of conditions caused by Candida albicans as it provides conditions that favour growth of yeast and release of its irritating endotoxins

Continue to apply miconazole cream for the full period of treatment as indicated

Paediatric dosage (ZA)

Forms avail. in SA and covered in this monograph: cre

South African registered indications and dosages

Infections caused by: Fungistatic against all Phycomycetes, Ascomycetes and Adelomycetes tested (e.g. Saprolegnia, Candida, Cryptococcus, Aspergillus, Dermatophytes, Phialophora, Sporotrichum) and fungicidal against Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Trichophyton interdigitale and Microsporum canis

Specific doses based on individual indications

Please note that the dosages below should be used in combination with regional guidelines, taking into account local antibiotic sensitivities

Dermatomycoses
- Tinea corporis (tinea circinata)
- Tinea manuum

Tinea cruris due to
- Trichophyton mentagrophytes
- Trichophyton rubrum
- Microsporum audouin
- Epidermophyton floccosum

Candidial infections
- Infections of the skin (.e.g. intertrigo)
- Perianal infections
- Stomatitis angularis (cheilitis, perleche)
- Balanoposthitis

  • See adult dosage

Dermatomycoses
- Tinea pedis (athlete's foot)

  • See adult dosage

Avoid occlusive dressings when this medication is used in the treatment of conditions caused by Candida albicans as it provides conditions that favour growth of yeast and release of its irritating endotoxins

Continue to apply miconazole cream for the full period of treatment as indicated

No specific dosages for children provided in South African manufacturer recommendations

Pregnancy & lactation

Pregnancy

South African recommendations

  • Caution
  • Safety of topical use during pregnancy has not been established

Breastfeeding

South African recommendations

  • Caution
  • Safety of topical use during breastfeeding has not been established

Fertility

South African recommendations

  • No information available

Renal impairment

  • Caution; no information available

Hepatic impairment

  • Caution; no information available

Elderly

  • Caution; no information available

Adverse reactions

Skin and Subcutaneous Tissue Disorders

  • Burning sensation
  • Skin inflammation
  • Skin hypopigmentation
  • Angioedema
  • Urticaria
  • Contact dermatitis
  • Rash
  • Erythema
  • Pruritus
  • Application site reactions
    - Irritation
    - Burning
    - Pruritus
    - Warmth

Immune, Blood and Lymphatic System Disorders

  • Anaphylactic reaction
  • Hypersensitivity

Interactions

  • Oral anticougulants
  • Warfarin

Monitoring

None routine

Mechanism of action

Miconazole nitrate is an imidazole antifungal agent and may act by interfering with the permeability of the fungal cell membrane. It possesses a wide antifungal spectrum and has some antibacterial activity.

Spectrum of activity: Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum audouinii, Candida albicans, Epidermophyton floccosum

Dosage forms

  • Cream

Formulation

Cream (per g) 20mg

  • Covarex (Meyerall)
  • Daktarin (Janssen) originator
  • Dermazole (Sandoz)
  • Sutharex Cream (MeyerZall Laboratories)

Also available in the following forms: Oral gel, vaginal cream and vaginal tablet.

COMBINATION PREPARATIONS

Hydrocortisone/ Miconazole

Cream (per g) 10mg/20mg

  • Daktacort (Specpharm)
  • Elozart (LeBasi)

References

1. SAMF_12th Edition_Page 180 2. SmPC: Daktarin 2% Cream, McNeil Products Ltd: Last updated on eMC: 25 Aug 2016; Downloaded online 7 March 2019 [https://www.medicines.org.uk/emc/medicine/22613] 3. https://drive.google.com/drive/folders/0B4_v8Xoq_6PoRE5TNUtIRmxfWjQ (07/2008_Janssen_Daktarin_cream) 4. https://drive.google.com/drive/folders/0B4_v8Xoq_6PoRE5TNUtIRmxfWjQ (06/2015_MeyerZall_Covarex_cream) 5. Standard treatment guidelines and essential medicines list for South Africa, Hospital level, 2017 6. U2D: Miconazole (topical): Drug information; Uptodate; Downloaded online 7 Mar 2019 [https://www.uptodate.com/contents/miconazole-topical-drug-information?search=miconazole&source=panel_search_result&selectedTitle=1~38&usage_type=panel&display_rank=1] 7. NAPOS The Drug Database for Acute Porphyria: D01AC02 Miconazole; Accessed online; 7 Mar 2019 [http://www.drugs-porphyria.org/languages/UnitedKingdom/s3.php?atc_code=D01AC02&l=gbr] 8. South African Institute for Drug-Free Sport: Dermazole; Accessed online; 7 Mar 2019 [http://www.drugfreesport.org.za/online-medication-check/] 9. SmPC: Daktarin 2% Cream, McNeil Products Ltd: Last updated on eMC: 05 Nov 2020; Downloaded online 24 Feb 2021 [https://drive.google.com/drive/folders/1wJmwh1YNMD3YtV7PI79V7vOVzxLxkpjh] 10. PI: Daktarin Cream, Janssen: Date of Registration: 25 July 2008 [https://drive.google.com/drive/folders/1wJmwh1YNMD3YtV7PI79V7vOVzxLxkpjh] 11. PI - COVEREX CREAM PACKAGE INSERT - Glenmark - Date of publication - February 2019 - Downloaded online 03 February 2026.pdf [https://www.sahpra.org.za/wp-content/uploads/2020/02/Daktarin-Cream_PI_Janssen_MCC-format-25-November-2011.pdf] 12. PI - Daktarin-Cream_PI_Janssen_MCC-format-Date of revision of text - 25-November-2011 - Downloaded online 03 February 2026.pdf [https://www.sahpra.org.za/wp-content/uploads/2020/02/Daktarin-Cream_PI_Janssen_MCC-format-25-November-2011.pdf] GHANA REFERENCES GH1. Ministry of Health Ghana National Drugs Programme (GNDP) Standard Treatment Guidelines, 7th Edition, 2017 [https://drive.google.com/drive/folders/1EQKbcrtqOU9qM1DpWgsS35ERYS_WkO_w] GH2. Ministry of Health Ghana National Drugs Programme (GNDP) Essential Medicines List, 7th Edition, 2017 [https://drive.google.com/drive/folders/1EQKbcrtqOU9qM1DpWgsS35ERYS_WkO_w]

Brands & products

7 products · cached snapshot
Trade names (4)
  • Covarex
  • Daktarin
  • Dermazole
  • Sutharex Cream

CRECream· 7 products

from R55.59
ProductStrengthPackApplicantMin price
Covarex2 g/100g25Meyerzall Laboratories (Pty) LtdR55.59
Sutharex Cream20 mg/g30MeyerZall Laboratories (Pty) LtdR59.83
Covarex2 g/100g30Meyerzall Laboratories (Pty) LtdR66.68
Covarex2 g/100g40Meyerzall Laboratories (Pty) LtdR88.87
Dermazole20 mg/g25Sandoz SA (Pty) LtdR107.90
Covarex2 g/100g50Meyerzall Laboratories (Pty) LtdR111.14
Daktarin Creamdiscontinued20 mg/g30Janssen Pharmaceutica (Pty) LtdR357.36

Medical aid coverage

data not yet integrated
Discovery Health
not yet integrated
  • Comprehensive Series—
  • Executive Plan—
  • KeyCare Series—
  • Priority Series—
  • Saver Series—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

Bonitas Medical Fund
not yet integrated
  • BonClassic—
  • BonComprehensive—
  • BonEssential—
  • BonFit Select—
  • BonSave—
  • BonStart—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

GEMS — Government Employees Medical Scheme
not yet integrated
  • Beryl—
  • Emerald—
  • Onyx—
  • Ruby—
  • Sapphire—
  • Tanzanite One—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

POLMED — Police Medical Aid Scheme
not yet integrated
  • Aquarium Option—
  • Efficiency Option—
  • Marine Option—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

Interacts with 28 known drugs

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Cited in 5 documents

NeoHealth® ID 15594 · updated 2/4/2026