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DrugsLevel 4 LocalisationS0SOLEML

Hydrogen Peroxide

Peroxide, oxidantAntiseptic

Indications

Registered South African indications:

  • Acute stomatitis
  • Deodorant gargle

Cautions

Contraindications

  • Hypersensitivity to the active ingredient or any of its excipients
  • Children < 2 years

Cautions

  • Contact with eyes

Adult dosage

Forms avail. in SA and covered in this monograph: sol

Acute stomatitis
Deodorant gargle

  • Oral (sol): Rinse mouth with 10ml reconstituted solution for 1min, and discard, 6hrly and at bedtime

Dilute to 1.5% before use as a mouthwash

Paediatric dosage

Not established for use in children below 2 years

Special populations

Pregnancy

  • Caution; no information available
  • Hydrogen peroxide is not absorbed systemically following topical administration. Inadequate data to determine risk, but unlikely to be harmful with limited topical use

Breastfeeding

  • Caution; no information available
  • No data to aid determine infant risk but is unlikely as hydrogen peroxide is not absorbed systemically following topical administration

Renal Impairment

Hepatic Impairment

Elderly

Porphyria Information

Drugs in Sport

  • Non-regulated product: Authorities caution athletes against the risk of using these products

Adverse reactions

Sensory Disorders

  • Unpleasant taste
  • Irritation 
  • Pain

Interactions

No information available

Monitoring

None routine

Mechanism of action

Hydrogen peroxide is used as a disinfectant and deodorant mouthwash. Hydrogen peroxide is an oxidizing agent with antiseptic activity. It releases oxygen when applied to tissues, which produces its oxidizing activity, with effect lasting only as long as the oxygen is being released and is of short duration. The antimicrobial effect of the liberated oxygen is reduced in the presence of organic matter. A 1.5% solution has been used as a mouthwash in the treatment of acute stomatitis and as a deodorant gargle.

Dosage forms

  • Solution

Formulation

Solution 3%

  • Hydrogen Peroxide Solution volume 10 

Solution 6%

  • Hydrogen Peroxide Solution volume 20

References

1. SAMF_11th Edition_Page 36 2. Pharmacologist Micormedex medicines information.  Martindale the complete drug reference, 36 th edition.  Meyer CT, Brand M, DeLuca VA, et al: Hydrogen peroxide colitis: a report of three patients. J Clin Gastroenterol 1981; 3:31-35.  Lau WY &amp; Wong SH: Randomized, prospective trial of topical hydrogen peroxide in appendectomy wound infection: high risk factors. Am J Surg 1981; 142:393-397.  SAMF, 12 th edition.  Product Information: ORAJEL(R) oral rinse, hydrogen peroxide oral rinse. Del Pharmaceuticals,Inc., Uniondale, NY, 2005. 3. https://www.medicines.org.uk/emc/medicine/25449 4. https://www.medicines.org.uk/emc/medicine/25265 5. https://www.uptodate.com/contents/hydrogen-peroxide-drug-information?source=search_result&search=hydrogen%20peroxide&selectedTitle=1~150 6. NAPOS The Drug Database for Acute Porphyria: Hydrogen peroxide; Accessed online 25 October 2018 http://www.drugs-porphyria.org/languages/UnitedKingdom/s3.php?atc_code=D08AX01&l=gbr 7. South African Institute for Drug-Free Sport: Hydrogen peroxide; Accessed online 25 October 2018 http://www.drugfreesport.org.za/online-medication-check/ *no drugs.com 8. Dr Irhuma's Updates. Updated 29 April 2020 [https://trello.com/c/IMx9Fa8P/301-hydrogen-peroxide-solution-antiseptic-disinfectant] 9. SmPC: Hydrogen Peroxide Solution 9% 30 Vols, Thornton & Ross Ltd. Updated 6 Sept 2019. Downloaded online 29 April 2020 [https://www.medicines.org.uk/emc/product/4870/smpc] 10. AfriTox: Hydrogen peroxide; Downloaded online 28 July 2020; Last accessed online 28 July 2020 [https://www.afritox.co.za/hp/SingleToxin/SingleToxin.aspx?SingleToxinID=3708]

Brands & products

0 products · cached snapshot
Trade names (1)
  • Hydrogen Peroxide Solution

Medical aid coverage

data not yet integrated
Discovery Health
not yet integrated
  • Comprehensive Series—
  • Executive Plan—
  • KeyCare Series—
  • Priority Series—
  • Saver Series—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

Bonitas Medical Fund
not yet integrated
  • BonClassic—
  • BonComprehensive—
  • BonEssential—
  • BonFit Select—
  • BonSave—
  • BonStart—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

GEMS — Government Employees Medical Scheme
not yet integrated
  • Beryl—
  • Emerald—
  • Onyx—
  • Ruby—
  • Sapphire—
  • Tanzanite One—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

POLMED — Police Medical Aid Scheme
not yet integrated
  • Aquarium Option—
  • Efficiency Option—
  • Marine Option—

Formulary scraper pending — coverage tier, co-pay and authorisation requirements will appear here once data is ingested.

Cited in 12 documents

NeoHealth® ID 16427 · updated 11/3/2022